Prostasomas: search of biomarkers for the early detection of prostate cancer
Journal Title: TecnoLógicas - Year 2019, Vol 22, Issue 44
Abstract
Prostate cancer is the second most diagnosed disease in men worldwide, with an increasing mortality rate in recent years. Currently, there are two early detection tests, the measurement of blood levels of prostate-specific antigen and digital rectal examination of the prostate. However, these tests do not present optimal specificity and sensitivity for their detection. Although different studies have looked for new biomarkers by means of the implementation of technologies, such as new generation sequencing, mass spectrometry, among others, the same disadvantages persist, therefore, they have not allowed their use in clinical practice; The discovery of new biomarkers for the diagnosis of prostate cancer is a challenge for the scientific community. Prostasomes correspond to extracellular vesicles secreted by normal prostate or tumor tissue that can be detected in different fluids. Structurally, prostasomes differ from other exosomes, by their size, membrane composition and specific protein content, which makes them a potential and novel source of clinical biomarkers. In this context, this review presents an overview of protein biomarkers, isolated from prostasomes present in different biological fluids, for the possible diagnosis of prostate cancer. For this, a systematic PubMed search was carried out for studies in proteomics for prostate cancer, with criteria such as extracellular vesicles, exosomes and prostasomes, as well as blood, urine, seminal fluid, among other biological samples.
Authors and Affiliations
Manuela Antonia García, Julieth Rueda, Johanna Pedroza-Díaz
Keywords
Related Articles
- EP ID EP549722
- DOI 10.22430/22565337.1181
- Views 95
- Downloads 0
Model of dynamic allocation of storage places in Cross Docking centers
This paper describes the methodology applicable to temporary storage in Cross Docking centers using a mathematical model. This model favors the dynamic allocation of storage places to incoming products in Cross Docking c...
CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study
Exposure to air pollutants like carbon monoxide (CO), lead (Pb++) and sulfur dioxide (SO2) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb++and SO2block L-t...
Evaluation and implementation of measurement uncertainty for determining stationary source emissions: a review
This paper presents a review of commonly-cited methods for estimating uncertainty in the literature. One of them is the non-stochastic approach proposed by the Guide to the Expression of Uncer...
Thermal behavior evaluation of solar dryers in a passive regime
This article presents the evaluation of the thermal behavior of three solar dryers in a passive flow regime designedfor the environmental conditions of the Colombian Caribbean Coast. Field experiments we...
Development of XLPE compounds with low-toxicity flame retardant for cable insulation
Nine formulations of a flame retardant masterbatch with low environmental impact were developed, and the influence of their incorporation into a linear low-density polyethylene, grafted with a vinyltrimethoxysilane cross...