Protective effect of an adenosine receptor agonist on neuropathic pain using chemotherapy induced neuropathy in mice.
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 1
Abstract
Neuropathy is defined as the pain condition that results from damage affecting peripheral nerves, posterior roots, spinal cord or certain regions of brain. Increased neuronal excitability is thought to be the underlying mechanism for all forms of painful neuropathies. The work was framed to study the adenosine based treatment for chemotherapy induced neuropathy. Involvement of adenosine in nociception created an interest to work for chemotherapy induced neuropathy. Tricyclic antidepressants (TCAs), though often the first choice in most patients causes sedation and cardiovascular issues, Anticonvulsants, like the TCAs, are only partially effective in the majority of patients, Opioids, though often prescribed for moderate to severe pain, are sometimes avoided because of their potential for dependence and tolerance, scheduling issues and side effects. Hence in order to overcome these side effects we made an attempt to develop a newer drug for the treatment. Mice were first treated with vincristine sulphate (100 µg/kg, i.v). A single intravenous dose of vincristine causes painful peripheral neuropathy. Then we administer drugs for five days after inducing neuropathic pain. Baseline and 5 days after induction of neuropathic pain hyperalgesia (mechanical) and allodynia (mechanical) of all groups were measured in order to confirm the development of neuropathic pain. Hyperalgesia and allodynia of drug treated group was compared on 5th day with vehicle treated group in order to confirm the effectiveness of drug in neuropathy pain. Hence adenosine was found to be significant against neuropathic pain in lower and also in higher dose. Hence adenosine may provide a better insight in the development of the newer drug for neuropathic pain.
Authors and Affiliations
Vishweswar Rao. V
Keywords
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