Protective effect of Canthium parviflorum against potassium oxonate induced hyperuricemia in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 3
Abstract
Canthium parviflorum, belonging to the Rubiaceae was a valuable source of new secondary metabolites, jused in ayurvedic system of medicine, for various disorders. Traditionally, various parts of Canthium parviflorum were used to treat oedema, dysentery, spasm, scabies, diabetes etc. It also used to eliminate uric acid as well as increase the urinary output. Current study was aim to evaluate the antigout property of ethanolic leaf extract of Canthium parviflorum. The study was conducted in both in-vitro and in-vivo models. Xantihine Oxidase inhibition method was used in in-vitro model and Potassium Oxonate induced hyperuricemia was adopted for in-vivo model. The Xanthine Oxidase inhibitor, Allopurinol was used as reference compound in both the models. Two dose levels (200 and 400mg/kg) of ethanolic leaf extract of Canthium parviflorum was evaluated against Potassium Oxonate induced hyperuricemia in SD rats. All the test drugs were administered once daily for 28 days and the protective effect was determined by measuring the plasma uric acid. In in-vitro model, the Canthium parviflorum showed Xanthine Oxidase inhibition activity and comparable as that of Allopurinol. In in-vivo model, both the doses of ethanolic leaf extract of Canthium parviflorum exhibited significant reduction in the plasma uric acid levels as compare to Potassium oxonate induced hyperuricemia in rats. From the results it was concluded that, ethanolic leaf extract of Canthium parviflorum produced antigout activity against Potassium oxonate induced gout in rats.
Authors and Affiliations
Asokan Balakrishnan Ramajayam
Keywords
Related Articles
- EP ID EP413356
- DOI -
- Views 111
- Downloads 0
Anti Cancer activity of Cinnamomum Malabatrum against Dalton’s ascitic lymphoma
The aim of the research is to find out new anti cancer drugs from indigenous plant which are potent, nontoxic or minimal toxic and to investigate the anti cancer activity of Cinnamomum Malabatrum. The powder of Cinnamom...
Triphala an innovative medicine of the centuries
TRIPHALA had been described from the Era of Charak and Sushruta as a medicine with multiple properties. The drug Triphala is a combination of fruits of Terminalia chebula Retz, Terminalia bellirica Roxb and Emblica offic...
Formulation and evaluation of herbal tablets incorporated with Strychnos potatorum and Punica granatum extracts for antidiarrhoeal activity
Plants are always an exemplary source of drug. In fact, many of the currently available drugs were derived either directly or indirectly from the plants. Diarrhoea affects people of all ages, due to several causes- maln...
Sub tenons anesthesia VIS a VIS peribulbar anesthesia for small incision cataract surgery: a teaching hospital based study
Cataract is a major causative factor for blindness in India. Cataract extraction is commonest surgery performed both in India and abroad and one of the key procedures for preventable blindness. The popular small incision...
Emergence of drug resistance of Acinetobacter at tertiary care hospital
BACKGROUND & OBJECTIVE Acinetobacter, although saprophytic, the emergence and spread of Acinetobacter in hospital environment is a major area of concern. . It has been associated with a wide variety of illnesses in hosp...