Rapid Perioperative Changes in the Quantitative Properties of Plasma Lipases and Lipoproteins in Morbidly Obese Surgical Patients
Journal Title: Journal of Diabetes and Obesity - Year 2017, Vol 4, Issue 2
Abstract
Background: The impact of bariatric surgery on abnormalities in blood lipids and lipoprotein metabolism during the perioperative period has been poorly studied. Objective: We studied the impact of bariatric surgery on the composition and quantitative properties of lipoproteins and the activity of lipases in the plasma of perioperative morbidly obese patients. Methods: We examined the plasma lipoproteins and lipolytic activities of 34 morbidly obese patients one month before surgery (OB), pre-anaesthesia (-S), post-anaesthesia (+S), and one day and one month after open Roux-en-Y gastric bypass (RYGB) surgery. Results: Surgical injury induced acute stress, as evidenced by transitory hyperglycaemia and elevated plasma levels of stress hormones. Lipid profiles revealed a significant reduction during surgery and the day after in the plasma levels of total cholesterol (p < 0.0001), which was mainly due to a decrease in low-density lipoprotein cholesterol (cLDL) and was confirmed with a significant reduction in the plasma levels of LDL (approximately 26% reduction). Significant (p < 0.0001) changes were detected in the plasma levels of high-density lipoprotein cholesterol (cHDL) as well as a significant decrease (approximately 19% reduction) in the plasma levels of HDL. A significant (p < 0.0001) rise was noted in the plasma levels of both Lipoprotein Lipase (LPL) (approximately 2.6- fold increase) and hepatic lipase (HL) (approximately 2.2-fold increase) on the day after surgery, occurring simultaneously with the maximum increase in C-reactive protein (CRP) and a day after the peak values for non-esterified fatty acid (NEFA), adrenocorticotropin hormone (ACTH), cortisol and glucose. Conclusion: The present study reveals unreported quantitative perioperative changes in plasma lipases and lipoproteins and related metabolic determinants that may contribute to the adaptive metabolic response to RYGB-induced stress. Summary: There was a significant rise in the plasma levels of plasma lipases on the day after surgery in morbidly obese patients, co-occurring with the maximum increase in C-reactive protein. Lipid profiles revealed a significant reduction during surgery and the day after in the plasma levels of cholesterol. Stress pre-/post-surgery caused important changes in NEFA, ketone bodies and other related parameters that could be used as markers of surgery risk.
Authors and Affiliations
Julia Peinado-Onsurbe
Keywords
Related Articles
- EP ID EP417858
- DOI 10.15436/2376-0494.17.1333
- Views 100
- Downloads 0
Gene Polymorphisms of Cytokines IFN γ +874 (A/T), TNF Α-308 (G/A), IL-6 -174 (G/C), L’il-10 -1082(A/G), -819 (C/T) -592 (C/A), TGF-β1 +869 (T /C), +915 (G/C) in Algerian Type 1 Diabetes and Latent Autoimmune Diabetes in Adults (LADA)
Background: We aimed to investigate the association between five cytokines IFN gamma 874 A T TNF Alpha -308 G A IL-6 -174 G C L rsquo il-10 -1082 A G -819 C T -592 C A TGF- beta 1 869 T C 91...
Association of Salivary and Plasma Glucose Level with Oral Health Status among Type 2 Diabetics in India - A Comparative Study
Background and Objectives: Diabetes is fast gaining the status of a potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the condition. Biochemical analysis of saliva would...
Trial for the Development of Bio-Functional Foods to Prevent Diabetes and Dementia Using a High-Pressure Treatment
emsp emsp Type-2 diabetes and Alzheimer rsquo s disease are very serious diseases and the former has been suggested to be one of the causes of the latter Low glycemic index foods inhibit rapid increases in blood glu...
Determining the Development of Insulin Resistance in Older Adults of the NuAge cohort Using Trajectory Modeling of the Homeostatic Model Assessment of Insulin Resistance Score
Background: Age-associated body composition changes increase the risk of developing insulin resistance. Identifying these subjects in epidemiological studies is challenging. Objective: Identify insulin-resistant subjects...
Is Being Underweight as Bad for Your Health as Being Obese? Evidence from the 2012 Behavioral Risk Factor Surveillance System
Background: Although there are indications that being underweight can compromise health status, most studies examine the health effects of obesity. A clearer understanding of the differential health effects of being unde...