Recent therapeutic developments in the antiphospholipid syndrome
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2003, Vol 20, Issue 6
Abstract
The antiphospholipid syndrome is characterized by thrombosis, recurrent abortions and detection of antiphospholipid antibodies. The management of acute arterial and venous thrombosis is no different from that of thrombosis of other etiology. Thromboprophylaxis can be achieved by long-term administration of oral anticoagulant therapy and warfarin can be used for this purpose. Thrombocytopenia may be managed by corticosteroids and for corticosteroid resistant thrombocytopenia other agents may be used, as well as splenectomy. The management of patients with positive antiphospholipid antibodies who have not suffered an episode of thrombosis consists of long-term follow-up, the removal of other risk factors and the long-term administration of low dose aspirin. Low dose aspirin can be used preconception in women with antiphospholipid antibodies as it may improve placentation. The administration of aspirin and heparin may reduce abortions in women with the antiphospholipid syndrome. In pregnant women with a history of thrombosis heparin should be used for the prevention of thrombosis recurrence, as warfarin can induce fetal damage. Pregnancy in women with the antiphospholipid syndrome should be managed by an expert team approach.
Authors and Affiliations
P. ATHANASIOU
Keywords
Related Articles
- EP ID EP82563
- DOI -
- Views 99
- Downloads 0
Παράγωγα της λέξης αίμα στην Αγγλική γλώσσα
Συγκριτική ανάλυση μελετών ικανοποίησης ασθενών σε νοσοκομεία στην Αττική
ΣΚΟΠΟΣ Τα διαχειριστικά συστήματα ποιότητας έχουν ολοένα και αυξανόμενο ρόλο στα συστήματα υγείας των αναπτυγμένων χωρών. Σταδιακά, νοσοκομειακές μονάδες επιχειρούν και ασχολούνται με την εφαρμογή των αρχών της ποιότητας...
Tyrosine kinase inhibitor –<br /> a new targeted therapy for chronic myeloid leukemia
The treatment of patients with Ph(+) or BCR-ABL(+) chronic myeloid leukemia (CML) did not improve very greatly in the 1990s. It is now widely accepted that patients treated by allogeneic stem cell transplantation may be...
Microalbuminuria and diabetic nephropathy: Epidemiology, prognostic significance, prevention
Diabetic nephropathy is a serious complication of diabetes and the leading cause of end-stage renal disease, at least in the US, Europe and Japan. Early detection of diabetic nephropathy relies upon tests for the urinary...
Biological agents and hepatitis
Hepatitis B virus (HBV) reactivation is a serious but preventable clinical complication of immunosuppression, with substantial morbidity and mortality, caused by immune reconstitution of specific immunity to specific vir...