Relation of Age, Gender and Bone Mineral Density to Vitamin D Levels in Osteoporosis in the Central Indian Population- A Retrospective Prevalence Study
Journal Title: International Journal of Medical Science And Advanced Clinical Research (IJMACR) - Year 2019, Vol 2, Issue 1
Abstract
Background: The function of vitamin D is to maintain serum calcium and phosphate concentrations, which are important for many physiological functions. Osteoporosis or bone loss is a disease characterized by the decrease of bone density and the tendency of bones to fracture easily.Objectives: To investigate the relation of vitamin D levels to osteoporosis in adults of Central Indian Population.Methods:This retrospective cross-sectional study comprised of 400 female and 400 male patient aged 20-70 years who were randomly sampled as three age groups as 20-35 years, 36-50 years and 51-70 years. Bone marrow density at the lumbar spine and femoral neck was measured by Bone density scan, serum concentrations of 25(OH)D and parathyroid hormone (PTH) levels were assessed.Results:The mean age of participants was 47.39 ± 19.32 years. Serum 25(OH)D levels were significantly lower in women than men (25.35 ± 6.59 ng/mL vs 27.25 ± 7.94 ng/mL, P < 0.05). The prevalence of 25(OH)D severe deficiency (<10 ng/mL) was 1.6% in men, zero in women; 25(OH)D deficiency (10-20 ng/mL) was 22.9% in womenand 20.5% in men; and 25(OH)D insufficiency (20-30 ng/mL) was 73.4% in women and 65.6% in men. An inverse relationship between serum 25(OH)D levels and age was observed in men, but no correlation was found in women. Serum 25(OH)D levels were positively associated with lumbar spine and femoral neck BMD in elderly women and in young men.Conclusion: A high prevalence of hypovitaminosis D and low BMD were observed in the 50-70 year age group of studied population.
Authors and Affiliations
Dr. Abhay Pratap Sing
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