Relationship between Serum Levels of Albumin and C - reactive protein (CRP) In Patients with Chronic Kidney Disease
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 2
Abstract
Protein- energy malnutrition, wasting and inflammation are frequent complication among patient with Chronic kidney disease (CKD). Malnutrition is associated with cardiac co-morbidity, inflammation and poor survival in CKD patients. Serum albumin is a well-known negative acute phase protein, marker of nutrition in CKD patients. C-reactive protein (CRP), the major acute phase response (APR) protein is elevated in these patients. High CRP levels are linked to the degree of atherosclerosis in coronary, peripheral, and extracranial brain arteries. The aim of the present study was to investigate nutritional factor (albumin) and CRP levels in CKD patients. This cross –sectional study was carried out in the Department of Biochemistry in collaboration with the Department of Medicine, Guru Gobind Singh Medical College & Hospital, Faridkot .Study involved 100 pre dialysis CKD patients (age 40.5 ± 12.3 years) admitted indoor and attending outdoor .Following investigations were carried out –CRP by fluorescence immunoassay method utilizing latex particles coated with CRP monoclonal antibodies (I-chroma). Serum albumin levels on fully automated chemistry analyzer Renal function by estimated glomerular filtration rate (eGFR). The data was later statistically analyzed. The study patients included 57 males (57%) and 43 females (43%) with average age of 40.5±12.3 years. The mean GFR was 38.3 ± 16.4 ml/min/1.73m2. The mean value of CRP was 10.93 ± 1.42 mg /dl. 67% of patients had elevated CRP (> 6 mg/L) with low serum albumin levels were present with mean value (3.02 ± 0.17 gm/dL). This study showed that low albumin and high CRP levels are the main predictors for death. There was a significant difference between CRP and albumin levels in CKD patients (P<0.001). Measuring CRP as a marker of inflammation can be helpful in managing these patients and Low levels of albumin are a marker of poor nutritional status in CKD patients. Our results indicate that CRP(as marker of inflammation) and albumin(as marker of nutritional status ) were very closely related to each other ,as the levels of CRP increased the albumin goes on decreasing due to degree of inflammation , malnutrition and decreased synthesis by liver exists in pre-dialysis CKD patients.
Authors and Affiliations
Kirti . , Sumit Kumar, Gitanjali Goyal, Cheenu Garg
Keywords
Related Articles
- EP ID EP543240
- DOI -
- Views 65
- Downloads 0
Significance of Serum Calcium in Young Adolescent Girls
Calcium, the mineral is essential for optimal growth and development of skeletal and teeth. Adequate calcium intake is critical during adolescence to optimize peak bone mass and decrease the risk of osteoporosis later in...
Anthropometric Indices, Inflammatory & Oxidative Stress Markers in Metabolic Syndrome
The present study was undertaken to investigate the variations of anthropometric indices, inflammatory oxidative stress and anti-oxidant markers in subjects with metabolic syndrome (MetS) compared to their age & sex-matc...
Assessment of Serum Cystatin-C and Serum Creatinine Levels among Sudanese Patients with Diabetes Mellitus in Khartoum State
Diabetes mellitus is a metabolic disorder resulting from insufficient insulin secretion, inefficient insulin action or both which lead to increased blood glucose, Diabetes is the most common cause of End Stage Renal Dise...
Study of Spot Urinary Protein/Creatinine Ratio as an Alternative for 24-Hour Urinary Protein in Pre-Eclampsia in and around Chitradurga
Pre-eclampsia is defined as new onset of elevated blood pressure and proteinuria after 20 weeks of gestation. Urinary protein-creatinine ratio has been used to evaluate proteinuria in pre-eclampsia. The presence of prote...
LDL and Small Dense LDL in Normal Pregnancy and Post partum
Normal pregnancy is associated with significant hyperlipidemia. Hyperlipidemias are well known as a modifiable risk factor for ischemic heart disease, which is one of the leading causes of morbidity and mortality worldwi...