Renal Function Deterioration After Radical Cystectomy and Analysis of Predictive Factors for Renal Deterioration
Journal Title: Üroonkoloji Bülteni - Year 2017, Vol 16, Issue 2
Abstract
Objective: Renal function deterioration develops in most of the patients treated with radical cystectomy (RC). In this study, we aimed to evaluate the changes in renal function of bladder cancer (BC) patients who had minimum 5 years of follow-up period after RC. Materials and Methods: In this study, 175 patients who underwent RC for BC at our institution between January 1995 and December 2010 were included. Age, gender, baseline glomerular filtration rate (GFR) before RC, tumor histology, pathological tumor stage, comorbidity record and presence of hydronephrosis before treatment were evaluated. GFR was calculated with the modification of diet in renal disease equation. GFR measurements of every 6 months were recorded in the follow-up. Results: The mean age and mean GFR before RC were 66.5±17.9 years and 91.1±18.2 mL/min, respectively. Patients separated into two groups for having ileal conduit diversion and ileal substitution (IS). It was found out that although baseline GFRs were similar for both groups, GFR was significantly lower in patients of RC with IS after the first year of follow-up period. According to multivariate logistic analysis, having IS as a diversion method (p=0.0001, odds ratio (OR): 3.2, 95% confidence interval (CI): 1.248-5.481), presence of diabetes mellitus record (p=0.0001, OR: 4.9, 95% CI: 2.575-9.706) and presence of hypertension record (p=0.0001, OR: 3.6, 95% CI: 2.019-6.552) were found to be associated with decrease in GFR. Conclusion: Renal function deterioration mostly develops in patients after RC surgery within 5 years. Renal function deterioration was more prominent in IS patients who had diabetes mellitus, hypertension record.
Authors and Affiliations
Nurullah Hamidi, Evren Süer, Mete Özkıdık, Uygar Bağcı, İlker Gökçe, Kadir Türkölmez, Yaşar Bedük, Sümer Baltacı
Keywords
Related Articles
- EP ID EP226690
- DOI 10.4274/uob.799
- Views 109
- Downloads 0
Bladder Leiomyoma in Men: Report of Two Cases and Review of the Literatüre
Leiomyomas, which originate from smooth muscle cells, are considered as a benign mesenchymal neoplasm and rarely seen in the bladder. The clinical presentation of bladder leiomyoma might vary according to the size and lo...
University of Health Sciences, İzmir Bozyaka Training and Research Hospital, Clinic of Urology, İzmir, Turkey
Granulomatous prostatitis, first described by Tanner and McDonald in 1943, is a histopathological diagnosis that includes mixed type inflammation with granulomas in the prostatic tissue. Granulomatous prostatitis compris...
Risk Adaptive Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer
Muscle invasive bladder cancer (MIBC) is an aggressive tumor with a high rate of early systemic dissemination. The main treatment for MIBC is still radical cystectomy and lymph node dissection. Survival rates for 5-year...
Which Patients Should Undergo Immediate or Deferred Cystectomy in Non-Muscle Invazive Bladder Cancer? Evaluation of Selection Criteria
Bladder cancer is the most common malignancy of the urinary tract in Europe. 70% of all muscle invasive is bladder cancer (MIBC) at the time of diagnosis whereas remaining 30% is non-muscle invasive bladder cancer (NMIBC...
Histopathologic Parameters Accompanying by Incidental Prostate Cancer
Objective: It is known that incidental prostate cancer (IPCa) can be seen in a low possibility for patients who were performed transurethral resection of the prostate (TURP) due to bladder outlet obstruction and/ or pro...