Renal Salt Wasting Syndrome due to Carboplatin in a Patient with Lung Cancer
Journal Title: Pulmonary Research and Respiratory Medicine – Open Journal - Year 2014, Vol 1, Issue 1
Abstract
A 40-year-old woman with lung cancer had multiple episodes of hyponatremia whenever she had chemotherapy with cisplatin plus etoposide and/or carboplatin plus etoposide over the last year. Although she had been diagnosed as having Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH), based on a multidisciplinary assessment, a diagnosis of Renal Salt Wasting Syndrome (RSWS) possibly due to carboplatin was made, and after completion of intravenous treatment with isotonic saline, hyponatremia resolved, and she was discharged uneventfully. Cisplatin is well known for causing renal toxicity via proximal tubular damage, some cases of which present as RSWS. However, RSWS is extremely rare with carboplatin. The differential diagnosis between RSWS and SIADH for hyponatremic patients is sometimes difficult because of similarities in their clinical features, but careful consideration is needed to make the correct diagnosis because their treatments are diametrically opposed.
Authors and Affiliations
Takeshi Saraya
Keywords
Related Articles
- EP ID EP550147
- DOI 10.17140/PRRMOJ-1-102
- Views 156
- Downloads 0
An Unbalanced Exon-Expression qPCR-based Assay for Detection of ALK Translocation (Fusion) in Lung Cancer
Non-Small Cell Lung Cancer (NSCLC) constitutes 85-90% of all lung cancer. Accurate diagnosis and selection of targeted therapies in lung cancer depends on robust detection of the molecular events that underlie its pathog...
Αlpha-1 Antitrypsin Gene Polymorphism in the Egyptian Population: Association with Obstructive Lung Diseases
Background: Given the potential adverse effects of asthma and Chronic Obstructive Pulmonary Disease (COPD), this study was undertaken to explore Alpha-1 Antitrypsin (AAT) polymorphism in the Egyptian population and its r...
Is Mycoplasma Pneumoniae Infection Associated with Adult Asthma Exacerbation?
Mycoplasma pneumoniae infection has been considered as a cause of initial onset of bronchial asthma1 or exacerbation of asthma.2 For example, Kraft, et al. showed that M. pneumoniae was detected by Polymerase Chain React...
Changes in Phosphoinositide Turnover in Airway Smooth Muscles and Blood Lymphocytes in Ova Sensitized Guinea Pig Model of Asthma
Background and Objective Bronchial asthma has been defined as a combination of reversible airway obstruction, increased airway responsiveness, and airway inflammation. Protein kinase C (PKC) is a primary group of enzymes...
Significance of Molecular Genotyping for Lung Cancer in Modern Oncology
Lung cancer is one of the most prevalent life-threatening diseases and remains the leading cause of cancer-related death worldwide. Although surgical resection of the tumor is considered as one of the most effective trea...