REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE ANALYSIS OF BUPROPION HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
A rapid and sensitive reverse phase HPLC method is depicted for the qualitative and quantitative assay of Bupropion hydrochloride in pharmaceutical dosage form. Bupropion hydrochloride was chromatographed on a reverse phase C18 column with a mobile phase consisting of methanol:phosphate buffer (pH-6) in the ratio of 80:20% v/v.The mobile phase was pumped at a flow rate of1ml/min. Aceclofenac was used as an internal standard and the eluents were monitored at 223 nm. The retention time of the drug was 5.7 min.With this method, linearity is observed between area under curve (AUC, expressed in mV.min) and concentration of Bupropion hydrochloride in the injected solution, in the range of 10-200 μg/ml.The method was found to be applicable for analysis of drug in tablets. The results of the analysis were validated statistically.
Authors and Affiliations
I Bhattacharyya
Keywords
Related Articles
- EP ID EP118925
- DOI -
- Views 111
- Downloads 0
ANTIDIARRHOEAL ACTIVITY OF PSEUDARTHRIA VISCIDA ROOTS
Aim of study: To evaluate the root extract of Pseudarthria viscida Linn, for antidiarrhoeal activity using standard model. Material and methods: The roots of Pseudarthria viscida Linn were collected from Kolli Hills, dr...
ANTIOXIDANT AND DNA BINDING STUDY 3,3'-(5,5'-METHYLENE BIS (3-MERCAPTO -4H-1,2,4-TRIAZOLE-5,4-DIYL)BIS(AZAN-1-YL-1- YLIDENE) DIINDOLIN-2-ONES
3,3'-(5,5'-methylene bis(3-mercapto-4H-1,2,4-triazole-5,4-diyl) bis (azan-1-yl-1-ylidene) diindolin-2-ones (VIIIa-t) have been synthesized by the condensation of an appropriate isatins (IIIa-t) with the intermediate 5, 5...
FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF BACLOFEN
The purpose of this research work was to establish mucoadhesive buccal tablets of Baclofen in the forms of monolayered tablets. The tablets were prepared using Sodium methyl cellulose (NaMC ), sodium alginate and Methoce...
NOVEL DRUG DELIVERY SYSTEM AND ITS USE IN THE TREATMENT OF ACNE
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and noninflammatory (comedones, ope...
VALIDATION OF REVERSED - PHASE HPLC METHOD FOR THE ESTIMATION OF CEFIXIME IN CEFIXIME ORAL SUSPENSION.
A simple, fast, precise and accurate, high performance liquid chromatographic method for estimation of Cefixime in Cefixime Oral Suspension was validated using C18 [Hypersil ODS], 4.6x250mm, 5 microns with mobile phase c...