Review on Diabetes Mellitus
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
Diabetes mellitus has reached epidemic proportions and affects more than 170 million individuals worldwide. In more developed societies, the prevalence of diabetes mellitus has reached about 6% and even more alarmingly, among obese white adolescents 4% had diabetes and 25% had abnormal glucose tolerance. Some 90% of diabetic individuals have Type-2 (Non-Insulin-dependent) diabetes mellitus, and within this category no more than 10% can be accounted for monogenic forms such as maturity-onset diabetes of the young and mitochondrial diabetes or late-onset autoimmune diabetes of the adult, which is actually late-onset Type 1 diabetes. People with diabetes have high blood sugar. This is because: Their pancreas does not make enough insulin and their muscle, fat, and liver cells do not respond to insulin due to insulin resistance. Insulin resistance is a state in which normal amount of Insulin produces a subnormal amount of Insulin response. There is an impaired biological response to insulin by one or more of its target tissues leading to reduced glucose disposal. Defects in binding of insulin to it’s receptors due to the reduction in their number or affinity would result in Insulin resistance. Clinically insulin resistance stage falls in two categories.
Authors and Affiliations
B. Yamini, , V. Leelaprabakar , P. Jayachandra Reddy
Keywords
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