PREPARATION OF ENTERIC COATED BEADS BY COACERVATION TECHNIQUE-A REVIEW
Journal Title: Int J of Pharm Rev& Res - Year 2012, Vol 2, Issue 1
Abstract
NSAID drugs having analgesic and anti-inflammatory effects are being widely administered orally in the treatment of mild to severe pain particularly for rheumatoid arthritis and osteo arthritis patients. Tolerance or addiction to these drugs is not generally a problem with their continuous use in the treatment of pain or in the treatment of acute or chronic inflammatory states. However, these drugs generally have a higher potential for adverse side effects at the upper concentration of their effective dose range therefore, it is important that such non steroidal anti-inflammatory drugs be accurately measured and administered orally. The non steroidal anti-inflammatory drugs like Ibuprofen and Naproxen have been widely prescribed by physicians. These drugs are in general tolerated well by most patients and provide an effective means for control of pain and inflammatory processes, particularly for the rheumatoid arthritis and osteo arthritis patients. However, most frequent adverse effects occurring with administration of Naproxen are gastro intestinal ulceration and bleeding. Enteric coated beads in which the drug is dispersed throughout the polymeric matrix efforts some protection to the gastro intestinal mucosa
Authors and Affiliations
P. R. Radhika , Para Sai Lakshmi , Evangelin Rani , Balaji Sadu
Keywords
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