Role of Cinnamon Extract in the Protection against Amoxicillin/Clavulanate-Induced Liver Damage in Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
Amoxicillin/clavulanate (AC), which is effectively used in the treatment of several number of bacterial infections, may cause hepatotoxicity. Cinnamon extract contains natural products which showed antioxidant, anti-inflammatory and anti-bacterial properties. In the present study, two doses of AC, therapeutic (30 mg/kg) and double therapeutic (60 mg/kg), were orally given to rats alone or in combination with cinnamon (200 mg/kg) for 10 consecutive days, to test the potential protective impact of cinnamon extract against AC-induced hepatic injury. Obtained results showed significant increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase(AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and total bilirubin in rats treated with AC. Hepatic contents of malondialdehyde (MDA), protein carbonyl (PC), hydrogen peroxide (H2O2) and nitric oxide (NO) were also markedly increased following administration of AC. On contrary, treatment with AC produced significant decreases in the hepatic levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase(GPx), glutathione reductase (GRd), glutathione-s-transferase (GST) and reduced glutathione (GSH). The drug was also found to induce upregulation of pro-apoptotic p53 and caspase-3 proteins expression, while it downregulated the expression of the anti-apoptotic protein Bcl-2 in the liver of treated rats. AC-induced adverse effects in all investigated biochemical indices seemed to be dose-dependent. However, administration of cinnamon extract along with AC to rats reduced liver injury, oxidative stress and apoptosis caused by treatment with AC alone. It could be concluded that cinnamon extract may be useful in the protection against AC-induced liver damage in rats.
Authors and Affiliations
Wafaa M. El- Kholy, Faried A. E. Hemieda, Ghada M. Elabani
Keywords
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- EP ID EP431613
- DOI 10.9790/3008-1401011421.
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