Background: Negative pressure wound therapy is relatively newer technique which consist of exposing wounds to negative pressure for accelerating wound healing and better wound care. Aim: To study role and efficacy of vacuum dressing in infected wound. Objectives: To have a comparative view about VAC dressing with other conventional dressing methods and to accelerate wound healing using VAC. Material and Methods: This prospective randomised study is carried out in MGM Medical College and Hospital Aurangabad between November 2015 and November 2017. The whole sample population was divided into two equal and comparable groups of 25 patients each. Selection of patients was done by random sampling method. Observation and Results: The decrease in mean size of wound. In group A (VAC) the pre-treatment size of wound is 66.36± 74.79 and in group B (Non-VAC) the pre-treatment size of wound is 36.36 ± 47.05. There was no statistical difference in pre-treatment size of wound in both the groups P=0.095. The post-treatment size of wound in group A (VAC) is 24.68 ± 23.07 and in group B (Non-VAC) the post treatment size of wound is 10.98 ± 13.48. There is significant statistical difference in post-treatment size of wound in test and control group P=0.011 and in group A (VAC) the wound showed signs of healing with development of healthy granulation tissue and angiogenesis averagely in 8.97 days where as in group B (Non-VAC) control group the healing with granulation tissue took place averagely in 21.6 days. The difference in healing between test and control group is statistically significant P < 0.001. Conclusion: VAC dressing is superior to conventional methods of wound dressing. The incidence of wound gaping dehiscence and conversion of acute to chronic wound is decreased as VAC dressing accelerates the formation of healthy granulation tissue and consequently faster wound healing is achieved.