Role of Orexin in Reproductive System
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Orexins (OX), OX-A and OX-B, were initially identified as hypothalamic neuropeptides primarily involved in the control of food intake and states of arousal. Thereafter, orexins have been substantiated as putative pleiotropic regulators of a wide diversity of biological systems, including different neuroendocrine axes. Among the latter, compelling experimental evidence has recently been documented that orexins, mainly OX-A, may act at different levels of the hypothalamic-pituitary-gonadal (HPG) axis to modulate reproductive function. However, orexin neurons are “multi-tasking” neurons that regulate sleep/wake states as well as feeding behavior, emotion, and reward processes. Orexin deficiency causes abnormalities in energy homeostasis, stress-related behavior, and reward systems. Male sexual behavior is altered by orexin receptor-1 agonists or antagonists, suggesting a role for orexin-A in this naturally rewarding behavior. However, the specific role of endogenous orexin-A or B in different elements of male sexual behavior is currently unclear. Therefore this review aims to explain the role of orexin in male and female reproductive system.
Authors and Affiliations
Abdinasir Isse, Yue-Hong Tao, Waleed Naji, Sami Ullah
Keywords
Related Articles
- EP ID EP600207
- DOI 10.9790/0853-160309122124.
- Views 85
- Downloads 0
Anaemia in pregnant women of Hyderabad (Telangana): prevalence, severity, associated risk factors and neonatal outcome
Background and purpose of the study: Anemia is a significant public health problem in India with a high morbidity and mortality, particularly in pregnant women and also adversely affecting fetal development and thus neon...
T-Cell Prolymphocytic Leukaemia: A Case Series
T-prolymphocytic leukaemia (T-PLL) is a rare mature T-cell lymphoproliferative disorder. It is seen more often in middle-aged and elderly individuals with a median age of onset of 65 years and a male predominance of 2:1....
Study of Serum Vitamin-C levels in Carcinoma Stomach
Introduction:- Stomach cancer is the leading cause of cancer related death worldwide, hence known as CAPTAIN OF MENS DEATH.Vitamin -c is an antioxidant and inhibitor of carcinogen N-nitroso compound production in the sto...
The Relationship between Adolescent Risk Behaviors and Family Structural and Process Factors: The Impact of Gender.
Family factors are important protective variables for adolescent development, risk behavior and outcome. Gender influences impact family interactions, rules and relationships. Adolescent cognitive, social and psycho emot...
Placenta Praevia- A Study On Maternal & Perinatal outcome
Objective: To determine the maternal & perinatal outcome in placentapraevia Method: It is a cross-sectional study carried out in a tertiarycare hospital. All pregnant women who were diagnosed to have placenta praevia wer...