T-Cell Prolymphocytic Leukaemia: A Case Series
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
T-prolymphocytic leukaemia (T-PLL) is a rare mature T-cell lymphoproliferative disorder. It is seen more often in middle-aged and elderly individuals with a median age of onset of 65 years and a male predominance of 2:1. Patients present with hepatosplenomegaly, lymphadenopathy, 15% may have serous effusions and approximately 20% have skin involvement. The white cell count is often above 200 x 109 /l, and the tumour cells are CD3+, CD4+ or CD8+ (co-expression of CD4 and CD8 in 25%), CD7+, and are CD25-. The disease has an aggressive clinical course due its inherently chemoresistant nature, with a median survival of 7 months on conventional chemotherapy. We report4 patients diagnosed with T-PLL all presenting within a year to academic hospitals in the Johannesburg area of South Africa. There is a scarcity of information on TPLL in South Africa where Human-immunodeficiency virus (HIV)-related haematological malignancies predominate in clinical practice.
Authors and Affiliations
Philippa Ashmore, Paul Ruff, Yusuf Mayet, Fotis Kouvelakis, ,Jenifer Vaughan, Tirelo Pitjadi, Reena Mohanlal, Elise Schapkaitz, Nicole Hollandf, Vinitha Philip, Muhammed F Waja, Atul Lakha, Moosa Patel
Keywords
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- EP ID EP597666
- DOI 10.9790/0853-1605086772.
- Views 72
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