ROLE OF RAMOSETRON AND ONDANSETRON IN LUCS AND LOWER LIMB SURGERY UNDER SPINAL ANAESTHESIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 2
Abstract
BACKGROUND Death or serious morbidity resulting directly from anaesthesia is now extremely rare. However, postoperative nausea and vomiting (PONV) is still very common. Therefore, every anaesthetist must be aware of the physiology of PONV and its consequences, causes, associated factors and management. Postoperative Nausea and Vomiting (PONV) after spinal anaesthesia for caesarean delivery and lower limb surgery (LLS) are distressing to both patients and surgeons. Spinal anaesthesia has been shown to be an easy, rapid and safe technique. Objective- To determine the efficiency of ramosetron and ondansetron in terms of prevention of nausea and vomiting intraoperatively and postoperatively in LSCS & LLS patients under spinal anaesthesia. MATERIALS AND METHODS Study Design- Randomised, double-blind study. In this randomised, double-blind study, 60 patients received either ondansetron (4 mg) or ramosetron (0.3 mg) intravenously 10 min. before the administration spinal anaesthesia. 60 patients of age group 20-30 years, ASA Grade I & ASA Grade II, body weight ranging from 45-65 kg were studied. All the patients were subjected to elective caesarean section or LLS under spinal anaesthesia. They were randomly allocated into two groups namely study group (30 patients received inj. ramosetron 0.3 mg IV)and control group (30 patients received inj. ondansetron 4 mg IV).Patients were observed intraoperatively, in the recovery room and in the ward up to 24 hours. For episodes of nausea and vomiting, Rescue antiemetic was given if the patients had PONV score 2 and was recorded. All the patients were observed for side-effects such as dizziness, headache, sedation or extrapyramidal reaction and accordingly up to 24 hours. RESULTS Incidence of nausea and vomiting in immediate postoperative period was 10% in study group compared to 20% in control group. Dizziness and headache were comparable in both the groups. CONCLUSION Ramosetron is quite effective to prevent nausea and vomiting in LSCS & LLS patients under spinal anaesthesia. It reduces the incidence of nausea and vomiting intraoperatively and in the immediate postoperative period.
Authors and Affiliations
Utpal Kumar Ray, Prasanta Kumar Mandal
Keywords
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- EP ID EP284570
- DOI 10.14260/jemds/2018/51
- Views 80
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