Royal Jelly Induced Anxiolytic Effects and Prevent Hot Flushes in a Menopausal Model on Wistar Rat
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 19, Issue 4
Abstract
Royal Jelly (RJ) is a creamy liquid secreted by bees for the nutrition of their larvae and the queen bee. Previous work has shown that RJ can bind to estrogen receptors and brings about the same effects as that of estrogens. The aim of this study was to evaluate the effects of RJ on menopause related anxiety and on hot flushes in Wistar rat. To do this, the Elevated Plus-Maze (EPM) and the Open Field (OF) test were used to evaluate the anxiolytic effects of royal jelly, while data loggers were used in the case of hot flushes. SHAM and OVX groups received distilled water. Three doses of RJ were tested (100, 200 and 300 mg/kg BW). Diazepam and estradiol valerate were used as reference drug. All the substances were administered per os, except diazepam(i.p.). As results, Royal jelly induced a significant increase (p< 0.01, p< 0.001) of the number of rearing and head dipping in the EPM test compared to OVX group. It also induced a significant decrease (p< 0.05, p< 0.01, p< 0.001) of the weight of faeces produced and the rectal temperature in the EPM. In the OF test, compared to OVX group, RJ significantly increased (p<0.05, p< 0.01) the centre square time and the number of rearing. It also induced a significant decrease of the number of grooming. The evaluation of hot flushes showed that, comparing with the OVX group, RJ led to a decrease in the total number as well as the frequency of hot flushes at all the doses tested compared to OVX group. These results suggest that royal jelly is capable of reversing some disorders related to estrogen depletion induced by ovariectomy. These anxiolytic effects and hot flushes prevention of royal jelly could justify it traditional use by women facing menopause. Menopause also known as the climacteric at short term, is the time in women lives when menstrual period stops permanently [1]. At a physiological level, menopause happens because of a cessation in ovarian hormones [2]. This decrease in ovarian hormones is responsible for some physiological disorders which include vasomotor disorders (night sweats and hot flushes), mood changes [3], anxiety and irritability. Statistically, 10 % of the world population suffer from several forms of anxiety [4] and 51% of these are menopausal women [5]. In the same light, 80% of menopausal women suffer from hot flushes [6].
Authors and Affiliations
Djiogue Sefirin, Adjoffoin Chiara Nange, Motoum Tedjo Florette, Zemo Gamo Franklin, Awounfack Charline Florence, Kamtchouing Pierre, Njamen Dieudonne
Keywords
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- EP ID EP622653
- DOI 10.26717/BJSTR.2019.19.003356
- Views 165
- Downloads 0
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