Schiff’s Bases Derived from Amino AcidsImidazole Conjugates as Promising Antioxidant and Antimicrobial Agents
Journal Title: Journal of Chemistry and Applied Biochemistry - Year 2015, Vol 2, Issue 1
Abstract
A series of amino acids conjugated imidazole derivatives were synthesized and characterized by standard spectroscopical techniques. The title compounds were evaluated for their in vitro antimicrobial activity against bacteria and fungi by zone of inhibition method. The results showed that this skeletal framework exhibited interesting potency as antimicrobial agents. Amongst, compounds 10,11,13,14,16,17 and 18 showed most potent gram negative and gram positive antibacterial activity whereas compounds 11,12,14,15,17 and 26 displayed most potent antifungal activity against A. niger and compounds 16,17,18, 21,22 and 24 exhibited good antifungal activity against F. oxysporum species. On the other hand, conjugates 11,12,13,14,15,16,17 and 18 showed very good antioxidant activity compared to commercial standard drugs. The results highlight the amino acids conjugated imidazole derivatives as potential leads for designing new future antimicrobial drug candidates possessing good antioxidant properties.
Authors and Affiliations
Channe Gowda
Keywords
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