Screening for the protective efficacy of two different extracts of Pithecellobium dulce in CCl4 and Isoniazid induced hepatic injury in wistar rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Hepatoprotective effect of ethanolic and hexane:benzene:acetone (1:1:1) extracts of Pithecellobium dulce (EEPD and HBAPD respectively) in carbon tetra chloride (CCl4) and Isoniazid (INH) induced toxicity in wistar rats was evaluated. Two parallel sets of experiments were performed. Hepatotoxicity was induced by either single dose of CCl4 or regular doses of Isoniazid (100 mg/kg b.w., i.p.). In both experiments standard drug (100 mg/kg, p.o.) and test extracts (500 mg/kg. p.o. for both) were given for ten days. Serum liver function enzymes were estimated spectrophotometrically. Both CCl4 and INH treated animals showed significant increased values of serum alkaline phosphatase, serum glutamic oxaloacitic transaminase, serum glutamic pyruvic transaminase and TBil (P<0.001 for all). However, these were found to be restored in one or both test extracts. The decreased values of these parameters were seemed to be less or more equivalent to standard drug. Present findings suggest that the PD extracts can ameliorate hepatic injury. However, different extracts showed similar protective activities against parameter used, in both experiments. Further investigations are needed to reveal the mode of action of the same.
Authors and Affiliations
Shweta Sharma1, B. K. Mehta2
Keywords
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