Sepsis-associated acute kidney injury – is it possible to move the needle against this syndrome?
Journal Title: Jornal de Pediatria - Year 2017, Vol 93, Issue 1
Abstract
On the one hand, sepsis is the leading cause of non-trauma related death in pediatric patients across the world, in both developed and developing nations.1 On the other hand, epidemiologic data demonstrate the independent contribution of acute kidney injury (AKI) to morbidity and mortality in both adults and children.2,3 The mortality, morbidity, and financial cost of AKI is significant and has led to dedicated global initiatives to eliminate preventable AKI and mitigate the effects of existent AKI.4 Together, unfortunately, sepsis and AKI synergize into the “worst of both worlds” – inciting a litany of negative host responses and ultimately leading to poor patient outcome. In this issue of Jornal de Pediatria, Riyuzo et al.5 report data on the predictive factors of death in patients with sepsis associated AKI. In their retrospective evaluation of 77 children with sepsis and AKI, the rate of severe AKI (pRIFLE stage I–F and/or stage 2–3 were both over 75%) and the overall mortality rate was substantial (33.7%).
Authors and Affiliations
Rajit Basu
Keywords
Related Articles
- EP ID EP510367
- DOI 10.1016/j.jped.2016.09.001
- Views 45
- Downloads 0
Translation and validation of Pediatric Quality of Life Inventory™ 3.0 Diabetes Module (PedsQL™ 3.0 Diabetes Module) in Brazil-Portuguese language
Objective The aim of the present study was to create a translated version of the Pediatric Quality of Life Inventory™ 3.0 Diabetes Module (PedsQL™ 3.0 Diabetes Module) in Brazilian Portuguese that was conceptually equiva...
Genomic imbalances in syndromic congenital heart disease
Objective To identify pathogenic genomic imbalances in patients presenting congenital heart disease (CHD) with extra cardiac anomalies and exclusion of 22q11.2 deletion syndrome (22q11.2 DS). Methods 78 patients negativ...
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives
Objective The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods This was a quasi-experimental study. The adolescents...
Musculoskeletal pain and musculoskeletal syndromes in adolescents are related to electronic devices
Objective To evaluate television and simultaneous electronic devices use in adolescents with musculoskeletal pain and musculoskeletal pain syndromes. Methods A cross-sectional study was performed in 299 healthy adolesce...
Effect of maternal vitamin A supplementation on retinol concentration in colostrum
Objective To investigate the effect of vitamin A supplementation on the retinol concentration in colostrum under fasting and postprandial conditions. Methods This was a quasi-experimental study, with before and after as...