Serum Protein Electrophoresis Patterns in Sero-Positive Human Immunodeficiency Virus- Individuals with Chronic Kidney Disease
Journal Title: International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) - Year 2017, Vol 4, Issue 2
Abstract
Various studies have reported a much higher incidence of monoclonal gammopathy among HIV–infected patients and also that serum protein electrophoresis patterns would be abnormal in HIV subjects. Hence this study was undertaken to study the pattern of serum protein electrophoresis in HIV- seropositive individuals with chronic kidney disease. Serum protein electrophoresis was performed in 100 HIV- seropositive individuals with chronic kidney disease and in 100 HIV-seronegative chronic kidney disease patients as controls. The mean age % HIV- seropositive individuals with chronic kidney disease was 57.2 years, with male-to-female ratio of 6:1. Of the HIV-seropositive patients, 42% showed polyclonal hypergammaglobulinaemia followed by nephrotic syndrome in 34% of patients. The HIV group also had hypo-gammaglobulinaemia in 8% of cases with only one case had monoclonal ‘M’ band. We found a remarkably high level (42%) of polyclonal hypergammaglobulinaemia in our patients compared with uninfected controls (28%).
Authors and Affiliations
Kowsalya R, Madhura NS, Mytri KM
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