Significance of glycemic status in patients of major depressive disorder with suicidal behaviour
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2017, Vol 23, Issue 1
Abstract
Background: Suicidal ideation is common in major depressive disorder, and it is thought to be a strong contributing factor for completed or attempted suicide. Hyperglycemia and hyperinsulinemia may increase the risk of depression and also suicide risk. herefore this study was conceived to explore the possible relationship between suicidal behaviour and impaired glucose metabolism in major depressive disorders. Materials and Method: This study was undertaken in Department of Biochemistry and Psychiatry, Government Medical College, Nagpur. 60 diagnosed cases of major depressive disorder in the age range of 21-60 years of either sex were enrolled. The diagnosis was determined by DSM IV criteria. HAMD scale was used to assess the severity of depression. Fasting and postprandial blood glucose along with HbA1c was determined in the study participants. Results: Out of 60 patients, nearly more than half of (53.33%, n=32) patients were having suicidal ideation and attempt. The male depressive cases (73.33%, n=22) outnumbered the female depressive cases (33.33%, n= 10) in having suicidal ideation and attempt. Statistically significant differences were found in fasting, postprandial blood glucose and HbAa1c of the major depressive cases with no suicidal ideation and behaviour, and with suicidal ideation and attempt. Conclusion: The observed association between blood glucose levels, HbA1c and suicidal behaviour suggests that disturbances in glucose metabolism are associated with suicidal ideation and attempts.
Authors and Affiliations
Mahendra T Kamble, Prashant V Dharme, Prerna D Nandedkar, Arvind V Gaikwad, Kamalakar B Mane
Keywords
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