Sildenafil Citrate Improves Ultrasound Doppler Velocimetry Indices in Foetal Growth Restriction – A Randomised Controlled Trial At A Tertiary Care Teaching Hospital in South India.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Background: Foetal growth restriction is an undesirable and challenging diagnosis given the dire foetal and neonatal consequences it is associated with. Ultrasound doppler velocimetry is a surveillance tool in such pregnancies as it illustrates foetal perfusion and nutrient availability. Materials & Methods: The study was conducted as a double blind placebo controlled randomized trial with 37 patients in study group who were administered Sildenafil 25mg TID and 56 patients in control group who were administered a similar placebo. Velocimetry indices in umbilical artery and middle cerebral artery were calculated at eligibility and one week post initiation of intervention. Differences in Sildenafil treated and Sildenafil naïve groups were analysed statistically. Secondary outcomes in terms of side effects were observed and analysed. Results: Sildenafil treated foetuses showed significantly higher decrease in RI (P-0.0003), PI (P-0.04) and S/D(P-0.008) in umbilical artery compared to control group. They also showed -15.115%, -5.526% and - 17.009% decrease in RI, PI and S/D respectively post eligibility in study group compared to -1.175%, -1.056% and -6.134% decrease in control group. Middle cerebral artery velocimetry showed a higher increase in RI (+17.204% vs. +7.355%), PI (+25.657% vs. +1.055%), S/D (+27.745% vs. +3.353%) in study vs. control group from eligibility to determination of effect. A significantly higher increase was also seen at determination in study group compared to control group with P values of 0.0002, 0.009 and 0.04 respectively for RI, PI and S/D. Conclusions: Sildenafil appears to significantly normalize ultrasound doppler velocimetry indices in foetuses affectted with late onset restriction.
Authors and Affiliations
Mohammed Ismail Khan, Asna Yasmeen, Mulaparthy Swetha
Keywords
Related Articles
- EP ID EP592330
- DOI 10.9790/0853-1602068692.
- Views 40
- Downloads 0
Epidemiology of Cervical Spinal Injuries in Government General Hospital, Kakinada, Andhra Pradesh.
Background; Currently there is no available information regarding the variety of cervical spine injury cases affected. Our study aim is to study the epidemiological prevalence of injuries, evaluation of management method...
Premorbid Social functioning in Schizophrenia, Bipolar Affective disorder and Healthy Controls – A Comparative Study
Objective of the study was to compare the premorbid social adjustment in patients with schizophrenia, bipolar affective disorder and healthy controls. Method: Maternal recall was used to assess the premorbid adjustment o...
“Study on The Effectiveness of Iron, Folic Acid, Vitamin B Complex And C for Reducing The Risk of Pre-Mature Ruptures of Membrane in Pregnancy”
Background: Preterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. Iron, Folic acid, Vitamin B Complex and Vitamin C plays...
Subclinical Hypothyroidism in type 2 diabetes mellitus patients
Introduction: Diabetes mellitus (DM) is the most common metabolic disease and its prevalence is increasing rapidly. Studies have reported that there is thyroid dysfunction in Type 2 Diabetes Mellitus patients. Subclinica...
Accessory Slip of Coracobrachialis: An Anatomical Variation
Coracobrachialis muscle arises from the tip of the Coracoid process of scapula, blends medially along with short head of Biceps brachii and is usually inserted into the medial border of the middle of the shaft of humerus...