Socio-demographic situation and environmental factors in childhood nephrotic syndrome
Journal Title: Medycyna Ogólna i Nauki o Zdrowiu - Year 2013, Vol 19, Issue 1
Abstract
Introduction: More and more attention is paid to environmental determinants of health and disease nowadays. Broadly defined environmental factors can not only cause the disease, but also modify its course or prevent it.Objective: The objective of the study was a retrospective evaluation of socio-demographic situation of patients with nephrotic syndrome (NS) and the influence of the selected environmental factors on its occurrence and course.Material and methods: The study concerned 123 children with NS hospitalized in the Department of Pediatric Nephrology in Lublin in years 2008 - 2012. An original questionnaire was created and used, and the available medical documentation was analyzed.Results: The age at onset was between 2 and 4 years in most children. Most of the patients were steroid responsive. The resistance to glucocorticoid therapy and steroid dependency were more common in girls than in boys. There was a statistically significant relationship between age at onset and the sensitivity to glucocorticoid therapy. There weren’t any significant associations between the place of residency, housing conditions, exposure to car exhausts or tobacco smoke, the history of allergic diseases, birth weight, intrauterine growth retardation, smoking by the mother during the pregnancy and: the age at onset and evaluated parameters of the course of NS. The children with the steroid resistant NS were briefly breast-fed, but that difference wasn’t statistically significantConclusions: The study confirmed the association between the age at onset of NS and response to glucocorticoid therapy. No statistically significant relationship was found between the course of NS and selected socio-demographic and environmental factors. Key wordsnephrotic syndrome, environment, children
Authors and Affiliations
Aleksandra Sobieszczańska-Droździel, Maria Małgorzata Zajączkowska, Paweł Droździel
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