Some Biochemical Effects of Methanolic Extract of Afzelia africana Seed in Rats Following Single or Repeated Carbon Tetrachloride Intoxication
Journal Title: Biotechnology Journal International - Year 2014, Vol 4, Issue 12
Abstract
Aim: To establish the in vivo effects of the methanolic extract of Afzelia africana seed on CCl4- induced organ damage on some biochemical parameters. Methods: The rats were divided into 7 groups of 5 rats each. In the single administration experiment, rats were intraperitoneally pre-treated with the extract (10mg/kg) for two days before CCl4 intoxication at 0.6ml/kg. In the repeated intoxication experiment, rats were administered the extract (5mg/kg) by intraperitoneal injection for 10 consecutive days, and CCl4 (0.6ml/kg) 72 hourly intervals for 10 days. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin (conjugated and total) were analyzed for hepatoprotective effect, while urea and creatinine were used to evaluate kidney function. Results: Data obtained showed significant reduction (P=.05) in the activities of ALT and AST, as well as in levels of bilirubin, urea and creatinine in the Afzelia africana extract-treated rats compared to the CCl4 control. Conclusion: These results indicate that the seeds of A. africana contain constituents that could protect the kidney and liver and ameliorate them from both acute and chronic injuries.
Authors and Affiliations
Sunday Ene-Ojo Atawodi, Uju Dorothy Iliemene
Keywords
Related Articles
- EP ID EP237781
- DOI 10.9734/BBJ/2014/13785
- Views 84
- Downloads 0
Phytochemical Screening and Cytotoxic Analysis of Three Local Vegetables Used in the Treatment of Bacterial Diarrhoea in Southern Benin (West Africa): A Comparative Study
The use of plants in traditional medicine become very common nowadays throughout the world and in developing countries in particular. The current study was carried out aiming to compare the chemical features of three veg...
Identification of Biomarkers of Stress in Meat of Pigs Managed under Different Mixing Treatments
Aims: The objective of this work was to apply the proteomic approach for identification of animal-based stress biomarkers during pig muscle maturation. Study Design: Pigs were subjected to management treatments that may...
Incorporation of Silver Nanoparticles with Natural Polymers Using Biotechnological and Gamma Irradiation Processes
Aim: In this study, silver Nanoparticles (AgNPs) was synthesized by two processes. Chemical process using natural polymers as citrus pectin (CP), chitosan (Cs) and alginate (Alg) and biological process using aqueous extr...
Production of Bioethanol from Wild Cassava Manihot glaziovii through Various Combinations of Hydrolysis and Fermentation in Stirred Tank Bioreactors
Aim of the Study: The aim of this study was to evaluate three ethanol fermentation approaches namely (I) separate hydrolysis and common fermentation (II) separate hydrolysis and fermentation and (III) simultaneous saccha...
Computational Molecular Analysis of the Sequences of PAPPA2 Gene of Selected Ruminants and Non Ruminants
Pregnancy associated plasma protein A2 (PAPPA2) is an Insulin-like growth factor binding protein (IGFBP) protease of the pappalysin family. This gene has been reported to be associated with prenatal growth, postnatal gro...