STATISTICAL, DIAGNOSTIC AND RESPONSE SURFACE ANALYSIS OF NEFOPAM HYDROCHLORIDE NANOSPHERES USING 35 BOX-BEHNKEN DESIGN
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: Objective of the current investigation was to analyze effects of operating conditions on characteristics of nefopam hydrochloride nanospheres (NFH-NS). Statistical assessment and diagnostic analysis examined an adequacy and reliability of models.Methods: NFH-NS were developed by quasi solvent diffusion technique using poly (meth) acrylates by 35 Box-Behnken design. Drug: polymer ratio (X1), surfactant concentration (X2), stirring time (X3), DP/CP Ratio (X4) and stirring speed (X5) were selected as independent variables. Response variables investigated were % entrapment efficiency (% EE), mean particle size, % process yield and % drug loading (% DL).Results: Standardized Pareto chart illustrated that X1 and X5 were important factors (p<0.05) affecting response parameters of nanospheres. Significant model F-value (p<0.05) and non-significant lack of fit F-value (p>0.05) epitomized an accuracy of data. Smaller value of predicted residual error sum of squares (PRESS) for regression models stipulated good fit of models. Diagnostic analysis proved normality of data and signified that actual values of response parameters were in agreement with predicted values. Graphical analysis concluded that X1, X2, X4 and X5 had the significant positive effect on % EE. X1 and X5 produced remarkable synergistic and antagonistic effect on mean particle size, respectively. X1 and X5 exhibited positive effect on % process yield. X1 produced significant antagonistic effect on % DL.Conclusion: Optimization report concluded that formulation prepared with 1:3 drug: polymer ratio (w/w), 2 % (w/v) surfactant, 3.8 h stirring time, 1:12 DP/CP ratio and 2000 rpm stirring speed was having highest desirability function of 0.920. Regression models indicated good fit of model, adequate model discrimination and concluded that models can be used to navigate design space.Â
Authors and Affiliations
Sukhbir Singh, Yash Paul Singla, Sandeep Arora
Keywords
Related Articles
- EP ID EP578221
- DOI -
- Views 99
- Downloads 0
PREPARATION AND CHARACTERISATION OF IBUPROFEN LOADED POLYMERIC NANOPARTICLES BY SOLVENT EVAPORATION TECHNIQUE
Objective: In the present study Ibuprofen loaded nanoparticles were prepared by solvent evaporation technique. Comparative study was done among the formulations to know the best stabilizer and the polymer for ibuprofen l...
CRYSTAL STRUCTURE PREDICTION IN THE CONTEXT OF PHARMACEUTICAL POLYMORPH SCREENING AND PUTATIVE POLYMORPHS OF CIPROFLOXACIN
Molecular simulation is increasingly used by medicinal chemists in the process and product development. Reliable computational predictions are of great value not only for the design of an active pharmaceutical ingredient...
DIELECTRIC RELAXATION STUDY OF BINARY MIXTURES AT DIFFERENT TEMPERATURES
Objective: The objective of this work is to study the intermolecular interaction and hydrogen bonding of the two binary mixtures at different temperatures which are determined from static dielectric constants and their e...
COMPARATIVE STUDY ON THE EFFICACY OF MOMETASONE AND FLUTICASONE NASAL SPRAYS FOR TREATMENT OF ALLERGIC RHINITIS
Objective: Allergic rhinitis is the most prevalent of allergic diseases in the world. Nasal corticosteroids are the most applicable drugs for the treatment of allergic rhinitis. In this study, we compared the efficacy of...
DEVELOPMENT AND EVALUATION OF KETOROLAC TROMETHAMINE MUCOADHESIVE BUCCAL TABLETS
Objective: The aim of the present study was to develop and evaluate buccal mucoadhesive tablets of ketorolac tromethamine.Methods: The tablets were prepared by direct compression using bioadhesive polymers such as carbob...