Stress response and antioxidant profile in Egyptian cows naturally infected with lumpy skin disease
Journal Title: Journal of Multidisciplinary Sciences - Year 2020, Vol 2, Issue 1
Abstract
Lumpy skin disease (LSD) is a severe disease of cattle that causes a broad spectrum of economic losses. The purpose of this study is to shed light on some physiological changes that may occur in the infected Egyptian local cows, including the primary and secondary stress responses besides the antioxidant profile. Two groups of Egyptian adult cows were used in the present study. The first group (control group) consisted of 10 clinically healthy cows, while the other one (infected group) consisted of 7 naturally infected LSD cases subjected to routine clinical examination. The clinical investigation revealed the presence of skin lesions passing through different progressive stages, starting from the appearance of nodules until the formation of deep scars. LSD was associated with a well-noted stress response, as exemplified by hyperglycemia, hyperlactatemia, and increases in serum cortisol, urea, and creatinine levels. Marked depletion in serum superoxide dismutase and catalase activities, vitamin E, malondialdehyde, and total peroxide levels were observed in the LSD challenged cows. These findings indicated the ability of LSD to induce stress reactivity and disturb the redox balance, and therefore the application of stress-management strategies and administration of dietary antioxidants are highly recommended to enhance the health status of infected animals. This study paves the road towards other works investigating the differential response of oxidative stress biomarkers to this disease according to its severity and stages and choosing the best antioxidant supplements
Authors and Affiliations
Nasser Sayed Abou Khalil, Hanan Salah Ahmed Waly
Keywords
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- EP ID EP683706
- DOI https://doi.org/10.33888/jms.2020.213
- Views 224
- Downloads 0
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