STUDY OF CLINICOHEMATOLOGICAL PROFILE AND NEUROLOGICAL MANIFESTATIONS OF VITAMIN B 12 DEFICIENCY IN CHILDREN
Journal Title: GJRA-Global Journal For Research Analysis - Year 2018, Vol 7, Issue 11
Abstract
Vitamin B12 deciency is an important and under recognised cause of anemia and neurological morbidity in children. As per previous studies from India iron deciency was most common cause for anemia. But from the past two to three decades prevalence of cobalamin deciency is increasing. This study aims to study the various clinical, neurological manifestations and hematologic prole of Vitamin B12 deciency anemia in children aged 6 months to 12 years. A total of 58 children with Vitamin B12 deciency were studied of which the most common age group affected were 1 to 4 years. Pallor, Anorexia, generalised weakness (100%), hyper pigmented knuckles (94%) and Hyper pigmented distal phalanges (90%), Glossitis (68%) were the most common presentations. The neurological features were seen in all the cases in 6 – 12 month age group. Leucopenia was seen in 74% and Thrombocytopenia in 49% cases. Early identication and treatment can prevent irreversible brain injury and its profound impact on neurological outcome of child.
Authors and Affiliations
Dr. C. V. Prathyusha, Dr. A. V. Ramakishore
Keywords
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