Study of coagulation profile in eclampsia patients
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 6, Issue 3
Abstract
Background: Normal pregnancy accompanied by changes in the coagulation and fibrinolytic system causing a hypercoagulable state. There is a distinct possibility of accentuation of the hypercoagulable state of pregnancy during eclampsia and pre-eclampsia. This study is undertaken to assess oagulopathy in the eclampsia patients by a method that is rapid, cheaper and easily available. The aim of our study are the changes in platelet count, Prothrombin time and Activated partial thromboplastin time in eclampsia patients and normal healthy patients in their third trimester. Methods: A comparative study from December 2015 to October 2017. Total 133 pregnant women in their third trimester. Out of 133, 100 healthy pregnant women as a control and 33 patients with eclampsia. Blood was drawn from the study subjects in Obstetrics ward and transported to the laboratory immediately for Platelet count, Prothrombin time (PT) and Activated partial thromboplastin time (aPTT). Results: It was observed that in eclampsia,21(63.63%) patients had Platelet Count in the range 0.6-1.6 and 12 (36.37%)had between 1.6-2.6. 3(9.09%) subjects had PT in the range 12-14 and 14(42.42%) had between 14-16, 09 (27.28) subjects had PT in the range of 16-18, 5(15.15) subjects had PT in the range of 18-20, 2 ( 6.6%) had between 20-22. Activated partial thromboplastin time in 1 (3.03%) subjects had aPTT in the range 25- 30,7(21.22%) had between30-35, 8 (24.24%) had between 35-40,8(24.24%)had between 40-45 and 9(27.27%) had between 45-50. Conclusion: Eclampsia patients were compared with healthy normal pregnant women. We can say that certain coagulation parameters such as raised PT, aPTT and low platelet count in eclampsia patients which was statistically significance.
Authors and Affiliations
Khushbu B Patel, Bharat V Bhetariya, Nandini J Desai
Keywords
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