Study of cutaneous adverse drug reaction in tertiary care hospital – A prospective study
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Cutaneous adverse drug reactions (ADR) are most common types of adverse reaction to drug therapy, almost any drug can induce skin reactions. Cutaneous ADR is any undesirable change in the structure or function of the skin, its appendages or mucous membranes and encompass all adverse event related to drug eruption, regardless of etiology. Aims and objectives: To Study cutaneous adverse drug reaction at tertiary care hospital. Material and Method: Study was conducted after obtaining permission from Institutional ethical committee. The study was carried out in the Department of Dermatology at tertiary care hospital from July to Jan 2015 Result :The most common suspected drug was found were Oral Antimicrobials - 23.14% followed by Injectable Antimicrobials - 20.25%, NSAID’S- 18.60% , Topical Steroids - 15.70%, Anti-epileptics - 7.02%, Anti- Tubercular - 4.55%, Topical clobetasole with Gentamicin - 3.72%, Oral steroids - 2.89%, Iron with Multivitamins - 2.07%, Blood and its products - 1.24% , Anti-cancer - 0.83 % respectively. Prevalence of Various cutaneous adverse drug reactions i.e. Maculopapular Rashes were found in 21.49% followed by Acute Urticaria in 17.36%, Fixed drug eruption in 14.46%, Alopecia in 12.81 %, Steven Johnson syndrome in 8.68%, Erythema Multiforme-7.85, Facial swelling with itching in 6.20%, Toxic epidermal necrolysis in 3.72%, Steroid induced purpura in 2.89, Acneform eruptions in 1.65%, Steroid induced Cushing syndrome in 1.24%, Angioedema in 0.83%, Miscellaneous in 0.83 Respectively. Conclusion: The most common suspected drug forcutaneous adverse drug reaction were Oral Antimicrobials, Injectable Antimicrobials, NSAID’S, Topical Steroids, Anti-epileptics, Anti- Tubercular and the most common cutaneous adverse drug reactions were Maculopapular Rashes, Acute Urticaria, Fixed drug eruption , Alopecia, Steven Johnson syndrome respectively.
Authors and Affiliations
Vishal M Ubale, Punam A Gosavi
Keywords
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