STUDY OF EFFECTS OF HYPERGLYCAEMIA ON ALANINE AMINOTRANSFERASE LEVEL IN TYPE-2 DIABETES MELLITUS PATIENTS.
Journal Title: International Journal of Basic and Applied Physiology - Year 2014, Vol 3, Issue 1
Abstract
Background: The spectrum of liver diseases which ranges from innocuous enzyme elevation to progressive chronic liver disease has been described in association with hyperglycemia. Mild chronic elevations of alanine aminotransferase (ALT) often reflect the underlying insulin resistance which is common cause of type2 diabetes mellitus. Aims: To study the correlation between Glycaemic controls (PP2BS) and the duration of hyperglycemia with respect to the ALT levels in type 2 diabetes patients. Study Design: A randomized case study Materials and methods: fifty eight patients with diabetes type 2 as per ADA criteria were included in study and patients with: i) Viral marker for HBV and HCV was positive, ii) alcoholic, iii )h/o chronic use of drugs that causes liver function alteration. (glitazone, acarbose, tamoxifen, amiodorone, diltiazem, steroids and statins) were excluded from the study. Post prandial blood sugar and Liver function tests were done. The results were compared by using suitable statistical methods. (Student’s unpaired t test and Pearson’s correlation cofficient)Results: The level of alanine aminotransferase (ALT) was high in the cases as compared to those in the controls. There was a positive co-relation between PP2BS and the duration of hyperglycemia with respect to the ALT levels. Conclusion: There is a positive correlation between PP2BS (post prandial blood sugar) and the duration of hyperglycemia with respect to the ALT levels
Authors and Affiliations
Bijal K. Panchal, Payal S. Jivani, Ashvin Sorani, Chirag Savliya, R. S. Trivedi, Shital Ghataliya
Keywords
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