Study of fibro Q test, AAR & APRI indices as markers of fibrosis in chronic liver disease
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Liver biopsy and ultrasound are the gold standard methods to assess liver fibrosis in chronic liver disease (CLD). Recently Fibrosis Quotient test (Fibro Q test), AST: ALT Ratio (AAR) & AST: Platelet Ratio Indices (APRI) are the three non-invasive and simple indices proposed for assessing liver fibrosis in CLD. Objectives of the study: To know the efficacy of the indices- Fibro Q test, AAR, APRI as markers of fibrosis in CLD and to know which among these indices would be a high sensitive marker in estimating fibrosis. Materials and Method: The study includes 60 subjects, out of which 30 were clinically diagnosed as CLD and were confirmed by abdominal ultrasound (USG) and 30 were age and sex matched healthy controls. Fasting blood sample was collected; and AST, ALT, prothrombin time and platelet count were analysed. Fibro Q test, AAR & APRI were calculated. Receiver operating characteristic (ROC) curves were constructed to compare the accuracy of these three non-invasive tests in predicting significant fibrosis in patients with CLD. Results: Fibro Q, AAR, APRI were significantly increased in cases compared to controls. Fibro Q is a better marker than AAR & APRI, in the prediction of significant liver fibrosis. Conclusion: Fibro Q test, AAR & APRI indices are efficient markers to evaluate liver fibrosis in patients with CLD. Fibro Q, a novel non-invasive test, is a high sensitive marker than AAR & APRI.
Authors and Affiliations
Shilpa A. , Krishnaswamy D. , Indumati V. , Vijay V. , Shanthala D.
Keywords
Related Articles
- EP ID EP296979
- DOI 10.18231/2394-6377.2017.0047
- Views 69
- Downloads 0
Correlation of anthropometric parameters with lipid profile in first year medical students
Introduction: Lifestyle related risk factors are prone to increase the burden of cardiovascular diseases. Thus, the study was carried out in the medical students who are more prone to develop lifestyle diseases because o...
Role of biomarker of Oxidative stress in preeclampsia
Objective: To evaluate the role of biomarker of oxidative stress in predilection of pregnancy induced hypertension. Material and Methods: A sample of 200 pregnant women was examined at department of Gynecology and obstet...
Analysis of serum ferritin levels in non-diabetic, prediabetic and diabetic individuals
Introduction: Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion, insulin resistance or both. In the initial asymptomatic phase there is hyperinsulinemia, as insulin resistance progress and be...
Thyroid function parameters, body mass index and serum lipid profile in subclinical hypothyroidism: a hospital-based study of effect of levothyroxine replacement therapy in Srinagar, Jammu and Kashmir
Introduction: The Present study aimed to assess the effect of levothyroxine replacement therapy on serum lipid profile and thyroid function parameters of patients on subclinical hypothyroidism. We also aimed to correlate...
Castelli risk indices as useful indicators of atherogenic risk in subclinical hypothyroidism
Introduction: Thyroid hormones play an important role in regulating lipid metabolism. Subclinical Hypothyroidism (SCH) is increased thyrotropin-stimulating hormone (TSH) with normal T3, T4 levels. SCH is associated with...