Study of hematological parameters in patients with diabetic retinopathy
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2018, Vol 25, Issue 3
Abstract
Background: Diabetic Retinopathy (DR) is the major cause of blindness among the working population and is the most common microvascular complication of diabetes. Diabetes Mellitus (DM) is a complex disease characterized by chronic hyperglycemia, metabolic abnormalities, and long term macro and micro vascular complications involving the blood vessels, eyes, kidneys, and nerves. The majority of morbidity and mortality associated with diabetes are due to hyperglycemia leading to diabetic complications. Larger platelets contain denser granules which are metabolically and enzymatically more active and have higher thrombotic potential. Mean Platelet Volume (MPV) indicates the activity and average size of platelets and increase in MPV is linked to increased thrombotic potential. Several studies have shown relation between platelet parameters like Platelet count and MPV with presence of vascular complications. Objectives: To study the hematological parameters in patients with diabetic retinopathy and to evaluate the association of platelet parameters with glycemic control and vascular complications in patients with diabetic retinopathy. Materials and Methods: This was a case control study carried out for 18 months in a tertiary care hospital in patients with diabetic retinopathy. Results and Discussion: Patients with DR had low normal hemoglobin level of 13.5 (+/- 1.1) gm/dl. The Red cell Distribution Width was increased in patients with DR (15.4). The ESR in patients with DR was increased. The platelet count had a positive correlation with fasting blood sugar, postprandial blood sugar and HbA1C in patients with DR. Conclusion: For identification of vascular complications in patients with Type 2 diabetes, platelet parameters can be used only as an accessory tool but not as a single reliable marker. It is recommended that hematological parameters should be analyzed along with glycemic index and fundus examination to look for retinal changes to rule out impending microvascular complication of diabetes mainly diabetic retinopathy.
Authors and Affiliations
A Sowmya Devi, T B Uma Devi, Erli Amel Ivan, Ramya G
Keywords
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