Study of QTc Dispersion in Electrocardiogram in Patients of Type-2 Diabetes Mellitus
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 2
Abstract
Introduction: QTc dispersion is a measure of the spatial dispersion of ventricular recovery time. Recent studies have found an association between cardiac autonomic neuropathy (CAN) and prolonged QT interval, which leads to increased mortality due to ventricular arrhythmias, silent ischemia, and cardiac arrest. In our study, we compared the QTc dispersion in electrocardiogram (ECG) in type-2 diabetes mellitus (DM) patients with that of the age- and sex-matched non-diabetics controls and studied the correlation between QTc dispersion and CAN in type-2 DM. Materials and Methods: In a hospital based case-control study, QTc dispersion was compared between the 120 type-2 DM patients (as cases), and 60 non-diabetic healthy age- and sex-matched subjects (as controls). CAN assessment was made using the standard Ewing and Clarke tests. QT interval was calculated manually in all the 12 leads of the ECG and corrected (QTc) using Bazett’s formula. The dispersion in the QTc interval (QTc max - QTc min) among the 12 leads in the ECG was calculated for each subject. Observations: Out of the 120 diabetic cases, 69 (57.5%) had evidence of CAN. Diabetics with CAN were having a significantly longer duration of diabetes and raised HbA1C as compared to diabetics without CAN and controls. Mean QTc dispersion (in msec) and mean QTc dispersion % among the diabetics with CAN (46.2 ± 17.6; 12.05%) were significantly higher as compared to the diabetics without CAN (25.3 ± 10.0; 6.45%, P < 0.01) and to the controls (23.36 ± 13.2; 6.37%, P < 0.01), respectively. Conclusions: QTc dispersion was significantly higher among the diabetic with CAN group as compared with the diabetics without CAN group indicating the association of increased dispersion in QT interval with cardiac dysautonomia. Thus, QTc dispersion can be a helpful indicator of CAN and sudden cardiac mortality among the diabetic individuals.
Authors and Affiliations
Suyash Tated, A Gupta, M K Parashar
Keywords
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