Study of the levels of lipid profile and MDA levels and their correlation in hypertensive chronic smokers
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 2
Abstract
Background: Atherosclerosis is the underlying process involved in coronary heart disease, peripheral vascular disease and stroke. Elevated plasma low-density lipoprotein cholesterol levels, lowered high-density lipoprotein cholesterol levels, and elevated blood pressure are associated with more extensive and more severe atherosclerosis and also associated with greater risk of clinical disease1. Chronic exposure to a biologically active agent such as cigarette smoke could influence atherogenesis by many possible mechanisms2. There is a positive association between smoking and advanced coronary atherosclerosis3,4. Aims and Objectives: 1) To study lipid profile and serum MDA (malondialdehyde) levels in chronic smokers and hypertensives. 2) To find out the correlation between lipid profile, MDA level, smoking and hypertension. Methods: We studied lipid profile and serum MDA in four groups, consisting of control, chronic smokers, chronic hypertensives and individuals who were chronic smokers +hypertensives. Lipid profile included serum total cholesterol (TC), triglycerides(TG), high density lipoprotein(HDL), low density lipoprotein(LDL),andVLDL. Serum MDA level was estimated as measure of lipid peroxidation Results: Serum TC was 250.19±15.36 in chronic smokers, 238.19±91.6 in chronic hypertensives and266.56±43.18 in individuals who were chronic smokers + hypertensive (p<0.001). Serum TG was 236.89±71 in chronic smokers, 226±76.23 in chronic hypertensives and242.14±23.48 in individuals who were chronic smokers + hypertensive (p<0.001), HDL level of chronic smokers were 32.18±46.02, 33.14±12.03 in chronic hypertensives and33.18±19.08 in individuals who were chronic smokers and had hypertension (p<0.001),serum LDL was 158.38±62.46 in chronic smokers, 137.16±42.15 in chronic hypertensives and152.75±36.74 in individuals who were chronic smokers + hypertensive (p<0.001), serum MDA levels of chronic smokers were 2.29±0.04, 2.16±0.05 in chronic hypertensives and2.32±0.18 in individuals who were chronic smokers + hypertensive (p<0.001). Conclusion: Findings suggest that smoking induces Oxidative stress, depleted antioxidant activities and subsequent alteration in circulating lipids in hypertension. Thus hypertensive smokers are more likely to develop severe form of hypertension and cardiovascular disease.
Authors and Affiliations
Pushpa S Rajan, Sunita M Aghade
Keywords
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