Study of uric acid, oxidative stress and antioxidant status in hypothyroidism and hyperthyroidism patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 2
Abstract
Thyroid disorders are more common disorders in India and worldwide. The aim of our present study was to estimate the levels of uric acid, the role of oxidative stress by assessing plasma malondialdehyde (MDA) levels and antioxidant status by estimating the levels of reduced Glutathione (GSH) and Vitamin-C (Ascorbic acid) in hypothyroid and hyperthyroid cases when compared with controls. For this, 50 diagnosed cases of hypothyroid and 50 hyperthyroid cases were included for the study. The findings were compared with 50 age and sex matched controls. A significant increase in the levels of uric acid in hypothyroid cases was observed and no statistical difference was observed between hyperthyroid cases and controls. Statistically significant increase in the levels of MDA and statistically significant decrease in the levels of reduced glutathione (GSH) and Ascorbic acid levels were observed in hypothyroid cases and hyperthyroid cases when compared with controls.
Authors and Affiliations
Gurupavan Kumar Ganta, G S R Kedari, H Ashwin Raj
Keywords
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