Study on the correlation between disorders of ammonia metabolism and Parkinson's disease
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 10
Abstract
Parkinson's disease (PD) is a neurodegenerative disease that occurs mostly in middle-aged and elderly people, and there is still a lack of effective treatments due to the unknown cause. In recent years, more and more evidence has shown that gastrointestinal microbiota plays an important role in the occurrence and development of PD. In this paper, based on the Braak hypothesis that PD originates from the intestine and combined with the theory of kidney deficiency and blood stasis in traditional Chinese medicine, we discussed the process of chronic damage to the central nervous system caused by disorders of ammonia metabolism in the state of imbalance of gastrointestinal microbiota and kidney deficiency and blood stasis, and concluded that ammonia was likely to be a key factor leading to PD.
Authors and Affiliations
YANG Wenxue, LI Min, LI Mingwei, YANG Minghui
Keywords
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