Study on the correlation between disorders of ammonia metabolism and Parkinson's disease
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 10
Abstract
Parkinson's disease (PD) is a neurodegenerative disease that occurs mostly in middle-aged and elderly people, and there is still a lack of effective treatments due to the unknown cause. In recent years, more and more evidence has shown that gastrointestinal microbiota plays an important role in the occurrence and development of PD. In this paper, based on the Braak hypothesis that PD originates from the intestine and combined with the theory of kidney deficiency and blood stasis in traditional Chinese medicine, we discussed the process of chronic damage to the central nervous system caused by disorders of ammonia metabolism in the state of imbalance of gastrointestinal microbiota and kidney deficiency and blood stasis, and concluded that ammonia was likely to be a key factor leading to PD.
Authors and Affiliations
YANG Wenxue, LI Min, LI Mingwei, YANG Minghui
Keywords
Related Articles
- EP ID EP723866
- DOI -
- Views 49
- Downloads 0
Expression and clinical significance of SEPHS2 in cutaneous malignant melanoma
Objective To explore the expression and clinical significance of selenophosphoric synthetase 2 (SEPHS2) in cutaneous malignant melanoma (CMM) by bioinformatics methods. Methods The mRNA microarray expression profiles r...
Analysis and reflection on survey results for oral diseases in 420 officers and soldiers of a western unit
Objective To investigate the oral health status of grass-roots troops, and combined with the investigation results, put forward the diagnosis and treatment range of oral sergeants in grass-roots troops for reference. Me...
Research on sleep regulation intervention method of transcranial alternating current stimulation in pilots
Objective In response to the current situation that pilots often need to break circadian rhythm for emergency missions, a sleep regulation intervention method of transcranial electrical nerve stimulation is studied to s...
GSDMD-N mediated hippocampal microglial pyroptosis in a rat model of brain injury after cardiopulmonary resuscitation
Objective To explore the activation and pyroptosis of microglia in the hippocampus after brain injury induced by cardiopulmonary resuscitation (CPR) in rats. Methods A rat model of brain injury after CPR was established...
Preliminary study of the effect of PD-L1 on the biological behavior of vascular endothelial cells in keloids
Objective To clarify the difference in the expression of PD-L1 in vascular endothelial cells of keloids and normal skin tissues, and to clarify the regulatory effect of PD-L1 on vascular biological behavior through in v...