Substantiation of the composition of surface-active substances in development of a cream with silver citrate
Journal Title: ScienceRise: Pharmaceutical Science - Year 2017, Vol 0, Issue 6
Abstract
<p>Pharmaceutical emulsions are now given increasing attention because they are widely used in medical practice. This became possible due to a qualitatively new level of scientific research and achievements in the field of emulsion systems creation, as well as expansion of assortment of auxiliary substances and use of new modern equipment. Emulsions are heterogeneous disperse systems that are potentially unstable. Therefore, the issue of stabilizing of emulsion systems is the main problem in area of emulsions technology.</p><p><strong>Aim.</strong> The aim of the experiment was to study structural and mechanical properties of concentrated emulsion systems, depending on the total concentration of surfactants, as well as investigation of colloidal and thermal stability of samples for substantiation of the composition of surfactants in the development of a cream with silver citrate.<strong></strong></p><p><strong>Methods.</strong> Pharmaco-technological methods of research were conducted in accordance with the requirements of the State Pharmacopoeia of Ukraine.<strong></strong></p><p><strong>Research results.</strong> Colloidal and thermal stability of the samples of emulsion cream with silver citrate was investigated. It has been established that the use of emulsifiers in concentrations of 4 % and 6 % does not provide physical stability. A dispersion analysis of the heterogeneous systems was carried out, which has shown that the samples obtained by using of the emulsifiers combination are homogeneous in size of particles of oil phase, which do not exceed 10 microns. The behavior of samples of the emulsion cream with silver citrate during and after mechanical destruction is investigated. The results guarantee stability of the system under the influence of mechanical processing during industrial production and use.<strong> </strong></p><p><strong>Conclusion. </strong>As a result of the experiment, the use of the combination of surface-active substances: emulsifier № 1 and cetostearyl alcohol of 8-10 % was used to stabilize the emulsion system with silver citrate</p>
Authors and Affiliations
Zhanna Polova, Ievgenii Gladukh, Halyna Kukhtenko
Keywords
Related Articles
- EP ID EP647881
- DOI 10.15587/2519-4852.2017.119890
- Views 138
- Downloads 0
Morphological and taxonomic study of oxyacanthae Zbl. section of crataegus L. genus by vegetative characteristics
<p>On the territory of Ukraine in the wild the most widespread the representatives of the Oxyacanthae Zbl section of the Crataegus L. genus (hawthorn), which has 31 species in the world's flora, 13 species in the Ukraini...
Analysis of the Ukrainian market of parapharmaceuticals for prevention of keloid scars
<p>An analysis of the anti-keloid parapharmaceuticals (AKPF) market, for preventing the formation of keloid scar (KS) and providing the population with affordable drugs is an urgent issue at this time. Doctors have not y...
Determination of the need for medicinal products of plant origin used for treating cardiovascular diseases
<p><strong>Aim</strong><strong> </strong><strong>of</strong><strong> </strong><strong>the</strong><strong> </strong><strong>study</strong><strong> </strong>is to determine the need for medicinal products of plant origin...
Identification and component analysis of triterpenoids in Monarda fistulosa L. and Ocimum americanum L. (Lamiaceae) aerial parts
<p class="xfmc1">Despite the progress in the creation of synthetic drugs, herbal medicines do not lose their relevance nowadays. Triterpenoids are quite common in the plant world and exhibit a wide range of biological ac...
Development of the procedure of quantitative determination of the biological active substances in the extract of a bupleurum aureum in the composition of a combined dosage form
<p>Nowadays, combined medicines are becoming more and more widespread. The combination of active pharmaceutical ingredients is necessary to increase the therapeutic effect or shorten the treatment period, or prevent poss...