SUSTAINED RELEASE DRUG DELIVERY SYSTEM
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
The oral route is the most popular route used for administration of drugs, which is due in part to the ease of administration and to the fact that gastrointestinal physiology offers more flexibility in dosage form design than most other routes. The terms Sustained release, prolonged release, modified release, extended release or depot formulations are used to identify drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. There are several reasons for attractiveness of these dosage forms: provides increased bioavailability of drug product, reduction in the frequency of administration to prolong duration of effective blood levels, reduces the fluctuation of peak trough concentration and side effects and possibly improves the specific distribution of the drug.
Authors and Affiliations
Navin Dixit, Sheo Dutt Maurya, Bhanu P. S. Sagar
Formulation and evaluation of Escitalopram fast dissolving tablets by direct compression method
The present study is an attempt to select the best possible diluent, disintegrant combination to formulate rapidly disintegrating tablets of Escitalopram which disintegrates in matter of seconds in the oral cavity, the...
FORMULATION AND EVALUATION OF CEFPODOXIME PROXETIL SUSTAINED RELEASE MATRIX TABLETS
Formulation of Cefpodoxime proxetil extended release matrix tablets. The aim of the present study is to develop a pharmaceutically stable, once a day robust formulation which will have similar clinical efficacy as that...
Preliminary phytochemical and toxicity studies of Oenothera biennis
The present investigation was carried out to evaluate the safety of methanol extract from leaves of Oenothera biennis by determining its potential toxicity after acute and sub acute administration in mice. For the acut...
Antioxidant property for lipophilic extract of Strobilanthes kunthiana flowers
Strobilanthes kunthiana flowers are found on the hill slopes of the Western Ghats at an altitude of 6000 to 7000 feet. It is a bright blue bell shaped flower. The uniqueness of the flower is that it blooms once in 12 y...
Development and validation of new RP-HPLC method for simultaneous estimation of drug ceftriaxone and vancomycin in tablet dosage form
A simple, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Ceftriaxone and Vancomycin was developed and validated according to ICH guidelines. The quantificatio...