Synergistic interaction between acetaminophen and carbamazepine in mice
Journal Title: Medicamentul Veterinar / Veterinary Drug - Year 2014, Vol 8, Issue 1
Abstract
This study aims to demonstrate the type of pharmacodynamic interaction and the demonstration of an antinociceptive action of fixed-ratio binary combinations between a non-opioid analgesic (acetaminophen) and an anticonvulsant (carbamazepine) as a rational way to treat pain. All experimental procedures used in this study were closely in line with international bioethical regulations on experiments conducted on laboratory animals. For quantifying the interaction, we used the method of the additive composite curve, which allows the quantitative assessment of the pharmacodynamic interactions of binary combinations in fixed proportion. The interaction between these substances is the synergistic (potentiation), as evidenced by the left shift of the regression curve of the combination compared to the composite additive curve. The statistical parameters of regression analysis reveal the synergism between the two substances (Zmix = 39.276 ± 7.54 mg / kg ( Zmix < Zadd ) the interaction index Ȗ = 0.387 , p < 0.05, tc = 3.753 , tt = 3.511 Fc = 10.825 , Ft = 4.260 ). The synergism between the two substances is explained by the specific action mechanisms of each substance
Authors and Affiliations
Lidia Chitac, Sorin Beschea, Monica Neamtu, Delia Bulea, Veronica Bild
Keywords
Related Articles
- EP ID EP121298
- DOI -
- Views 74
- Downloads 0
Values for serotonin as an indicator for the dogs’ emotional state – Case study on eight dogs
The study was carried out on 8 mixt-breed dogs, ages 1-8 years old, which we took blood samples from in order to determine the serotonin content at four differnet moments. The first moment of blood sampling was registere...
Date preliminare privind unele manifestări ale durerii într-un model de șobolan MPTP-indus a bolii Parkinson
Boala Parkinson (BP) este mai puțin cunoscută ca o boală care generează durere, deși durerea este prezentă la 40-80% dintre pacienții cu BP, așa după cum este descris de foarte puține rapoarte în această ramură a cercetă...
Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography
The study describes the development of a HPLC -DAD method for the estimation of oxytetracycline and furazolidone in Enteroguard M - powder. The proposed method utilizes a Betasil C 18 column, (4.6 x 250 mm, 5 µm), at 300...
Procesul de dezinfectare al aerului și suprafețelor prin formarea unei cei foarte fine de 5 μm, fără umezire, pe baza de peroxid de hydrogen – nocolyse generată de nebulizatorul Nocospray
Nocospray este un concept revolutionar destinat bio dezinfectiei profesionale, cu actiune bactericidă, virucidă, fungicidă si sporicidă, utilizând ca substantă activă peroxidul de hidrogen în combinaie cu argint colo...
Report regarding the microbiological quality control of the veterinary pharmaceutical products during 2014
The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products, on the out of specification products...