SYNTHESIS AND ANTI-EPILEPTIC ACTIVITY OF SOME NOVEL 3-(4-(4-(SUBSTITUTED BENZYLIDENEAMINO)-5-MERCAPTO-4-1,2,4-TRIAZOLE-3-YL)PHENYLIMINO)-1-((DIMETHYL AMINO) METHYL)-5-FLUOROINDOLIN-2-ONE DERIVATIVES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: Synthesis and anti-epileptic evaluation of some novel Schiff and Mannich bases of isatin derivatives.Methods: A series of novel 3-(4-(4-(substituted benzylideneamino)-5-mercapto-4-1,2,4-triazole-3-yl)phenylimino)-1-((dimethyl amino) methyl)-5-fluoroindolin-2-one Schiff and Mannich base derivatives were synthesized by using various aromatic aldehydes with isatin derivatives. The chemical structures of all synthesized compounds were confirmed by IR, 1H-NMR, Mass spectra and elemental analysis. All the synthesized compounds were screened for its anti-epileptic activity by MES and scPTZ methods using Phenytoin and Ethosuximide as standards.Results: The results of anti-epileptic activity showed that some of the synthesized compounds were exhibited significant results.Conclusion: This investigation identified the potent anti-epileptic agents and these molecules will be subjected to further studies in our laboratory.Â
Authors and Affiliations
Cr Prakash, Sundararajan Raja, Govidaraj Saravanan
Keywords
Related Articles
- EP ID EP579769
- DOI -
- Views 78
- Downloads 0
GREEN SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES FROM AQUEOUS EXTRACT OF BASELLA ALBA AND THEIR IN-VITRO ANTIOXIDANT POTENTIALS
Objective: To synthesize silver nanoparticles (AgNps) from Basella alba(B. alba) aqueous extract using 3 mM AgNO3 solution, to characterize the resulted AgNps and also to study the antioxidant activity by DPPH and reduci...
FABRICATION OF A NANOCARRIER SYSTEM CONTAINING PLASMA PROTEIN BY OPTIMIZATION USING RESPONSE SURFACE METHODOLOGY
Objective: the present investigation involves formulation, optimization and in vitro characterization of size controlled HSA nanoparticles with reproducible process yield.Methods: Human serum Albumin (HSA) is material of...
ANTIDIABETIC ACTIVITY OF LINALOOL AND LIMONENE IN STREPTOZOTOCIN- INDUCED DIABETIC RAT: A COMBINATORIAL THERAPY APPROACH.
Objective: To demonstrate the efficacy of a protein glycation inhibitor (limonene) and antihyperglycemic plant component (linalool) in combination towards better management of diabetesMethods: Antihyperglycemic activity...
IN VITRO STUDIES ON Α-GLUCOSIDASE INHIBITION, ANTIOXIDANT AND FREE RADICAL SCAVENGING PROPERTIES OF TECOMA STANS L.
Objective: Tecomo. stans (T. stans) Â (L) are plants extensively used for the empirical treatment of diabetes mellitus. But the bark part of T. stans (L) has not been extensively studied for the anti-diabetic and antioxi...
DEVELOPMENT OF CASHEW GUM AND ITS DERIVATIVES FOR SUSTAINED RELEASED DRUG DELIVERY SYSTEM: BY RESPONSE SURFACE METHODOLOGY
The aim of the present study was to investigate the Cashew gum (CG) and its modifications for formulating the sustained release delivery system using theophylline (TH) as a model drug by varying the gum to drug ratio (1:...