Synthesis, Characterization, and Biological Activity of some Mixed-Ligands Vital Metal Complexes of Levofloxacin as Potential Medical Agents
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2018, Vol 29, Issue 29
Abstract
Two series of mixed-ligands metal complexes of Fe(III), Ni(II), Cu(II) and Zr(IV) based on levofloxacin as primary ligand, 8-hydroxyquinolene and 1,10-phenanthroline as secondary ligands were prepared and characterized by elemental and thermal analysis, magnetic susceptibility measurements, IR, UV-Vis. and ESR spectroscopic techniques. The study showed that levofloxacin interacted with the metal ions as a mono basic bidentate ligand bound to the metal through the pyridone and one carboxylate oxygen atoms, 8-hydroxyquinoline bonded to metal ion with its phenolic oxygen and ring nitrogen while 1,10-phenanthroline interacted through two ring nitrogen atoms thus producing stable mixed ligand complexes.The antibacterial activity of the complexes was tested against four different microorganisms where it was found that the complexes exhibited either comparable or increased antibacterial profile in comparison to the parent drug. The cytotoxic activities of some selected mixed ligands complexes were tested against HEPG2 cell line and compared to that of Vinblastine as a standard drug. The structural and molecular orbital calculations of the compounds were investigated theoretically by performing density functional theory (DFT) to investigate the structure, dynamics, surface properties, and thermodynamics of the inorganic systems. The calculated HOMO and LUMO energies showed that intramolecular charge transfer occurs within the molecules.
Authors and Affiliations
Islam M. I. Moustafa, Helmy E. Megahed, Tamer S. A. El – Baddally
Keywords
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