SYNTHESIS, CHARACTERIZATION, AND DNA- BINDING INTERACTION STUDIES OF A NEW MANNICH BASE AND IT’S METAL COMPLEXES
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 10
Abstract
Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important biological and pharmaceutical uses such as antibacterial, antifungal, anticonvulsant, antitumor and antinociceptive. In spite of these activities, much of their action mechanisms at molecular and cellular levels remain to be elucidated. A new series of nickel(II) and copper(II) complexes of a new mannichbase1-((2,5-dioxopyrrolidin-1-yl)(4-methoxyphenyl) methyl) thiourea (LIGAND) have been synthesized. The structures of newly synthesized compounds have been explicated on the basis of elemental analysis, molar conductance, IR, UV-Visible, NMR, Mass, and Magnetic measurements. The binding of the copper sulfate complex of the ligand with calf thymus DNA has been investigated using absorption spectroscopy, fluorescence spectroscopy, and viscosity measurements.
Authors and Affiliations
S. Sudhasankar
Keywords
Related Articles
- EP ID EP656737
- DOI 10.13040/IJPSR.0975-8232.10(10).4513-20
- Views 108
- Downloads 0
THE PATTERN OF ANTIBIOTICS PRESCRIPTION AT AL-RASS HOSPITAL
Background: The irrational uses of antibiotics play a crucial role in emerging of antimicrobial resistance. So regular review of the prescribing patterns represents an effective monitoring study that enhances rational pr...
ANTIANXIETY AND ANTIDEPRESSANT ACTIVITY OF VALERIANA PYROLAEFOLIA
Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract w...
REALISTIC DEFORMATION AND REMOVAL OF SOFT TISSUES MODELING FOR THE SIMULATION OF VIRTUAL SURGERY
Most of the simulation methods for soft tissue modeling involve tetrahedral meshes which is quite complex and takes much computation time. Instead, this work attempts to make use of delaunay triangulated mesh that consis...
DEVELOPMENT, CHARACTERIZATION AND IN-VITRO ANTIFUNGAL EVALUATION OF PLANTEROSOMAL GEL OF GANODERMA LUCIDUM
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifu...
COMPOUNDS FROM TROPIDIA CURCULIOIDES AS INDUCERS OF APOPTOSIS IN CANCER CELLS
Arunachal Pradesh (AP), the North-eastern state of India, is a natural habitat of 550 species of orchids including 37 species of medicinal importance. Though these plants are used extensively by locals for various ailmen...