Synthesis, characterization and Evaluation for Anxiolytic activities of some Novel 4-Thiazolidinone Derivatives
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 5
Abstract
The objective of the present work is to synthesis of N-[2-(4-substituted phenyl)-4-oxo-1,3-thiazoldine-3-yl]-2-(naphthalene-2-yloxy) acetamide and evaluate for anxiolytic activity. Based on this a new series of compounds have been planned to synthesize by reacting β-napthol, ethyl chloroacetate, hydrazinemonohydrate, ethyl alcohol and various aromatic aldehydes. The Anxiolytic activity of the test drugs were evaluated using the experimental Elevated Plus Maze (EPM) and Light-Dark Model (LDM) in mice. The result exhibit the anxiolytic activity among the three synthesized compounds at varying degree. Some compounds also exhibited skeletal muscle relaxant activity . Keywords: 4-Thiazolidinone Derivatives, Anxiolytic activity, Elevated Plus Maze, Light Dark Model.
Authors and Affiliations
Asish Bhaumik, A Narayana Reddy, M. Ashok Chandra, G. Neelamma
Keywords
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