SYNTHESIS OF 6, 7-DISUBSTITUTED-2-ARYL-4H-1-BENZOPYRAN-4-ONES AS ANTIBACTERIAL AGENTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Benzopyrones constitute one of the major classes of natural products. Both semisynthetic and natural benzopyrone derivatives are known to possess important biological properties and as a result several attempts and procedures have been reported and developed for their synthesis. The present study was designed to synthesize various substituted 2-aryl-4H-1-benzopyran-4-one derivatives. The title compounds were prepared starting from a diketone i.e. 4-substituted-2-hydroxydiaroylmethane. The structures of these newly synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were subjected for antibacterial screening against P.aeruginosa, B.subtilis and E.coli. Among all the derivatives 5d showed maximum activity against P.aeruginosa & E.coli and 5b showed highest activity against B.subtilis & E.coli. The results of the antibacterial screening suggest that some of the substituted 2-aryl-4H-1-benzopyran-4-one derivatives possess appreciable antibacterial activity and may prove useful in future drug development.
Authors and Affiliations
Sukhen Som , K. N Jayaveera
Keywords
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