Targeted Agents and Resistance Mechanism in Renal Cell Cancer
Journal Title: The Bulletin of Urooncology - Year 2019, Vol 18, Issue 2
Abstract
Renal cell carcinoma (RCC) exhibits multidrug resistance protein P-glycoprotein expression due to the proximal tubular origin and in this regard, it is resistant to a large number of cytotoxic chemotherapy. The identification of the molecular pathogenesis, genetics, and epigenetics of RCC has led to new target points such as vascular endothelial growth factor. Tyrosine kinase inhibitors have been used mainly for treatment, but recently, immune checkpoint inhibitors have also been used in the treatment of RCC. Despite these treatments, response rates are not sufficient in the majority of patients. Primary resistance or acquired resistance to the treatment might be seen. Defining these resistance mechanisms will contribute to the management of the treatment and will help in to identify new treatment targets. In this review, we focus on the molecular mechanisms and resistance mechanisms of targeted-therapy.
Authors and Affiliations
Shaghayegh Rezapourbehnagh, Hatime Arzu Yaşar, Çağatay Arslan, Yüksel Ürün
Keywords
Related Articles
- EP ID EP48742
- DOI 10.4274/uob.galenos.2018.1090
- Views 292
- Downloads 0
The Factors Affecting Recurrence and Prognosis in Patients with Low-grade Stage Ta Bladder Cancer
Objective: This study aims to review the parameters affecting tumour recurrence, tumour progression and cancer survival of patients with low-grade non-muscle invasive bladder cancer. Materials and Methods: We retrospect...
Magnetic Resonance Imaging Findings of Multilocular Cystic Renal Cell Carcinoma and Clinical-pathologic Comparison
Objective: Multilocular cystic renal cell carcinoma (RCC) is a unique type of renal carcinoma characterized by multi-loculated cystic masses. The aim of this study was to retrospectively evaluate the magnetic resonance i...
Contemporary Trends in Adrenal Sparing Surgery
Adrenal gland surgery has been practiced by the urologists ever increasingly in line with their interest in this particular field. Total adrenalectomy which is the classical approach for adrenal masses, is replaced by th...
Evaluating the Effects of Different Ischaemia Techniques on Functional Outcomes of Laparoscopic Partial Nephrectomy
Objective: This study aimed to investigate the influence of different ischaemia techniques on short-term and one year renal function following laparoscopic partial nephrectomy (LPN). Materials and Methods: Data of 359 p...
The Role of Multiparametric Magnetic Resonance Imaging to Detect the Extracapsular Extension in Robot- Assisted Radical Prostatectomy
Objective: This study aimed to evaluate the effectiveness of multiparametric prostate magnetic resonance imaging (mpMRI) in detecting extracapsular extension (ECE) and its impact on our preoperative surgical plan. Mater...