The Factors Affecting Recurrence and Prognosis in Patients with Low-grade Stage Ta Bladder Cancer
Journal Title: The Bulletin of Urooncology - Year 2021, Vol 20, Issue 1
Abstract
Objective: This study aims to review the parameters affecting tumour recurrence, tumour progression and cancer survival of patients with low-grade non-muscle invasive bladder cancer. Materials and Methods: We retrospectively reviewed 262 patients with primary, low-grade Ta bladder cancer. Recurrence was defined as the occurrence of a new tumour in the prostatic urethra or bladder. Tumour progression was defined as confirmed high-grade Ta, all T1 or carcinoma in situ, upper tract recurrence or progression to T2. The associations between factors that affect recurrence and progression were analysed. Results: Tumour recurrence and progression occurred in 119 (45.4%) and 25 (9.5%) patients during follow-up (median follow-up: 50.9±36.3 months), respectively. Univariate and multivariate analyses demonstrate that smoking, multiple tumours and large tumours (3 cm<) were significant. A Cox regression analysis revealed that progression was identified as a significant risk factor on survival. There was no effect of smoking on recurrence-free survival. A Kaplan-Meier analysis showed that one-, five- and ten-year progression-free survival rates were 99.6%, 88.2% and 70%, respectively. Conclusion: Multiple tumours, large tumours (>3 cm) and smoking were risk factors for recurrence and progression. Prevention of smoking and routine cystoscopic examination are essential in bladder cancer.
Authors and Affiliations
Mustafa Latif Özbek, Mehmet Özen, Süleyman Öner, Fatih Kocamanoğlu, Murat Gülşen, Mehmet Necmettin Mercimek, Yakup Bostancı, Şaban Sarıkaya
Keywords
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- EP ID EP693534
- DOI 10.4274/uob.galenos.2020.1558
- Views 112
- Downloads 0
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