Taste masked, orally disintegrating tablet containing microspheres for immediate release
Journal Title: Journal of Pharmacy Research - Year 2008, Vol 1, Issue 2
Abstract
The purpose of this study was to evaluate the potential of microspheres for taste masking when incorporated intoorally disintegrating tablets. The microspheres were produced by emulsification solvent evaporation method usinga model drug theophylline with a taste masking polymer. The solvent evaporation method was optimized to obtainmicrospheres with desirable characteristics. The microspheres were mixed with other excipients to form orallydisintegrating tablets. Optimization using two factors and three levels using factorial approach was carried out. Themicrospheres were best formed using acetone in 40 ml liquid paraffin at 1600 rpm speed of stirring for 90 minutes.The yield was 85 ± 2 %, particle size was 315 ± 10.84 μ and the assay results showed entrapment of 93.77 ±0.53 % drug. The tablets formed showed a hardness of 3 ± 0.5 kg/cm2 and in vitro disintegration of 25 ± 3seconds. The in vitro drug release was 88 ± 4 % at the end of 30 minutes. In conclusion, microspheres caneffectively mask the bitter taste of the active pharmaceutical ingredients in combination with the orally disintegratingtablets.
Authors and Affiliations
Supriya Shidhaye*, Vilasrao Kadam
Keywords
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