The Antidepressant-Like Effects of Menthol Via Dopaminergic System Using Forced Swimming Test in a Mice Model
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Background and purpose: Antioxidants are known to have protective and beneficial effects in the depression. Menthol is an antioxidant compounds in some plants. On the basis of our knowledge, no scientific study has investigated the antidepressant-like effects of menthol. Therefore, present study was thus conducted to evaluate the antidepressant-like effects of menthol by forced swimming test (FST) through dopaminergic system in a mice model. Materials and Methods: The mice were intra-peritoneally (i.p.) administrated with menthol (10-30 mg/kg) 1 h before the FST. For evaluating the involvement of the dopaminergic system in the antidepressant activity of menthol, SCH 23390 (a dopamine D1 receptor antagonist), sulpiride (a dopamine D2 receptor antagonist) and haloperidol (non-selective dopamine receptor antagonist) were administered 15 min before menthol administration (10 mg/kg). Results: Intra-peritoneally administration of menthol reduced immobility time and increased swimming and climbing times. It did not also cause significant changes in spontaneous locomotor function in the open-field test (OFT). In addition, pre-treatment of the mice with SCH23390, sulpiride, haloperidol blocked the anti-immobility effect of menthol in the FST. Conclusion: Administration of menthol exerted antidepressant-like effects through dopaminergic (D1 and D2) system.
Authors and Affiliations
Morteza Ghasemi, Arefeh Vafaeinejad, Golareh Mohaghegh Daghigh, Nasrollah Moradikor
Keywords
Related Articles
- EP ID EP677961
- DOI 10.29088/GCNR-2020.52
- Views 202
- Downloads 0
Vitamin D3 Supplement Rescues Motor Disability in 3-Nitropropionic Acid Induced Mouse Model of Huntington’s Disease
Background: The major outcome of all neurodegenerative disorders including Huntington’s disease (HD) results in loss of brain cells called neurons. Neuronal loss in the striatum, the major brain region responsible for m...
Prenatal Zinc Supplementation Improves Working Memory Impairment and Inflammatory Response in LPS-Induced Maternal Immune Activation Model
Introduction: Maternal exposure to infectious agents such as lipopolysaccharide (LPS) is known as a significant environmental risk factor which increases the risk of schizophrenia or other neurodevelopmental disorders i...
Modulation of Cholinergic Activity in the Hippocampus and Behavioral Alterations Induced by Prenatal Administration of Valproic Acid in Rats
Autism spectrum disorders (ASD) are defined by behavioral deficits in social interaction and communication, repetitive stereotyped behaviors, and restricted interests. The etiology of autism is not known. Neurotransmitt...
Memantine Improves Social Behavior and Prevents Developmental Retardation in Rats Exposed Prenatally to Valproic Acid
Autism spectrum disorders (ASD) is a group of neurodevelopmental disorders which are characterized by impairments in communication and social interaction, repetitive behaviors and a limited repertoire of interests and...
Memory Enhancing Effect after Medial Septum Stimulation is Associated with Changes in Hippocampal Cholinergic and Gabaergic Activity
Many brain disorders cause impairments in learning and memory. These include developmental disorders, as well as diseases of old age such as Alzheimer’s disease. People with these disorders often show changes in the hi...